蛋白酶激活受体在牙周组织细胞中相关作用的研究进展  

Research progress of protease-activated receptors on different types of cells in periodontal tissue

作　　者：卢可心 张迪亚[2] 吴燕岷[1] Lu Kexin;Zhang Diya;Wu Yanmin(Dept.of Oral Medicine,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Dental Department,The Affiliated Sir Run Shaw Hospital,Affiliated Hospital of ZhejiangUniversity School of Medicine,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属第二医院口腔内科,杭州310009 [2]浙江大学医学院附属邵逸夫医院牙科中心,杭州310016

出　　处：《国际口腔医学杂志》2019年第6期657-662,共6页International Journal of Stomatology

基　　金：国家自然科学基金（81000447）;浙江省科学技术厅公益研究计划（LGF18H140003）;浙江省自然科学基金（LY17H140002)~~

摘　　要：蛋白酶激活受体是一种可被多种内源性和外源性蛋白酶激活,参与炎症反应且分布广泛的跨膜蛋白。国内外研究者主要阐述不同类型蛋白酶激活受体在牙周炎中的作用,尚未出现系统性分类陈述蛋白酶激活受体在牙周组织不同细胞中的作用。本文就蛋白酶激活受体分别在牙龈上皮细胞、牙龈成纤维细胞、成骨细胞、破骨细胞、免疫细胞等牙周组织不同细胞中的表达及与牙周炎相关作用等研究进展进行综述。Protease-activated receptors(PARs), which are widely expressed transmembrane proteins, may induce inflammatory response once activated by a variety of endogenous and bacterial enzymes. Gingival epithelial cells, gingival fibroblasts, osteoblasts, osteoclasts, monocytes, macrophages and T lymphocytes exist in the periodontal tissue. In the development of periodontitis, the activated PARs of these cells are involved in the release of inflammatory factors and chemokines that cause gingival inflammation and alveolar bone destruction. Up-to-date data has shown the roles of PAR-1 and PAR-2 in periodontitis. However, the roles of PARs in hinge on different types of cells in the periodontal tissue have not been reviewed. Thus, the present review will focus on the current progress in the expression and functions of PARs.

关 键 词：蛋白酶激活受体 牙龈上皮细胞 牙龈成纤维细胞 成骨细胞 破骨细胞 

分 类 号：Q26[生物学—细胞生物学]