牙髓干细胞成骨微环境的研究进展  

Advances of dental pulp stem cells in osteogenic microenvironment

作　　者：周婷茹 李永生[2] Zhou Tingru;Li Yongsheng(School ofStomatology,Kunming Medical University,Kunming 650032,China;Dept.of Oral and Maxillofacial Surgery,YunnanFirst People’s Hospital,Kunming 650032,China)

机构地区：[1]昆明医科大学口腔医学院,昆明650032 [2]云南省第一人民医院口腔颌面外科,昆明650032

出　　处：《国际口腔医学杂志》2019年第6期675-679,共5页International Journal of Stomatology

基　　金：云南省科学技术厅-昆明医科大学应用基础研究联合专项(2017FE467-209)~~

摘　　要：牙髓干细胞具有高度增殖及多谱系分化的潜能,使其在联合生物支架材料修复口腔颌面部骨组织缺损方面具有独特的优势和前景,是骨组织工程学中关键的优选细胞。为了更好地实现骨组织的再生,需要为牙髓干细胞的成骨分化提供一个适宜的微环境。本文对牙髓干细胞成骨分化微环境中的细胞因子、支架材料及药物的研究进展进行综述。Dental pulp stem cells possess high proliferation rates and multi-lineage differentiation potential. These features provide them with unique advantages and prospects in the repair of oral and maxillofacial bone tissue with bioscaffold materials. Hence, dental pulp stem cells are optimised cells in bone tissue engineering. To enhance the regeneration of bone tissue, a suitable microenvironment is necessary for the osteogenic differentiation of dental pulp stem cells. In this review, we will examine the research progress of cytokines, scaffolds and drugs of dental pulp stem cells in an osteogenic microenvironment.

关 键 词：牙髓干细胞 成骨分化 细胞因子 支架材料 药物 

分 类 号：Q254[生物学—细胞生物学]