原子力显微镜在细菌黏附力学研究中的应用  

Role of atomic force microscopy in research on microbial adhesion force

作　　者：王蕊 盖阔[1] 刘梦齐 蒋丽[1] Wang Rui;Gai Kuo;Liu Mengqi;Jiang Li(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept.of GeneralDentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院全科门诊

出　　处：《国际口腔医学杂志》2019年第6期687-692,共6页International Journal of Stomatology

基　　金：四川省科技计划项目(2016FZ0069)~~

摘　　要：原子力显微镜作为重要的表面成像及力学探测工具,凭借其纳米级(nm)时空分辨率、皮牛级(pN)力灵敏度、液相环境等优势在微生物形貌力学探测中发挥了重要作用。本文简述了基于原子力显微镜的多种成像模式、力谱技术及二者相结合应用的最新进展,并综述了近年来原子力显微镜在细菌与基底、细菌与细菌及细菌与细菌生物膜的黏附力学特性研究方面的应用,为细菌黏附力学的深入研究提供了新思路。As a powerful tool for surface imaging and mechanical detection, atomic force microscopy(AFM) plays an important role in the exploration of microbial morphology and mechanics because of its advantages of nanometre resolution, piconewton force sensitivity and liquid imaging. This paper outlines the latest advances in various imaging modes and force spectroscopies and the cooperation of these technologies based on AFM. It also introduces the applications of AFM in the study of adhesive mechanical properties between bacteria and substrates, bacteria and bacteria, bacteria and bacteria biofilms, thereby providing a new way to research bacteria adhesion mechanics.

关 键 词：原子力显微镜 细菌黏附 相互作用力 

分 类 号：R37[医药卫生—病原生物学]