间充质干细胞通过调控巨噬细胞极化实现免疫应答的研究现状  

Current status of immune response of mesenchymal stem cells by regulating the polarization of macrophages

作　　者：何萌 陈娟 伍金林 He Meng;Chen Juan;Wu Jinlin(Department of Pediatrics,Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University ,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院儿科出生缺陷与相关妇儿疾病教育部重点实验室

出　　处：《中华妇幼临床医学杂志（电子版）》2019年第5期492-496,共5页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省卫生计生委重点项目资助(16ZD019)~~

摘　　要：间充质干细胞(MSC)是一种具有自我更新及多向分化潜能的多能干细胞,是细胞移植治疗的研究热点。既往认为,MSC主要通过细胞替代达到治疗疾病的目的。近年多项研究结果表明,MSC在调控免疫应答、抑制炎症反应中,也具有重要作用。新生儿缺血缺氧性脑病(HIE)是引起新生儿死亡和伤残的重要原因。对HIE采取MSC移植治疗,可减轻缺血缺氧引起的炎症损伤,加速神经修复。然而,MSC的免疫调控作用并不是与生俱来的,而与局部炎症微环境密切相关,在不同水平炎症因子的刺激下,MSC可表现出截然不同的免疫作用。深入探讨MSC的免疫调控机制,有助于进一步对其临床应用进行研究。笔者拟就炎症微环境刺激下,MSC的免疫调控作用及其机制进行阐述。Mesenchymal stem cells (MSC) are stem cells with abilities of self-renewal and multidirectional differentiation. In the past, MSC have been considered to achieve therapeutic effects mainly through cell replacement. However, a number of studies have shown that MSC play an important role in regulating immune response and inhibiting inflammatory response. Hypoxic ischemic encephalopathy (HIE) of neonates is an important disease that causes death and disability of neonates. Studies have proved that MSC transplantation can reduce inflammatory injury caused by ischemia and hypoxia, and accelerate nerve repair. However, the immunomodulatory effect of MSC is not innate, but closely related to the local inflammatory microenvironment. Under the stimulation of different levels of inflammatory factors, MSC may show distinct immune effects. In-depth understanding of its immune regulation mechanism is conducive to further research on its clinical application. Therefore, this article elaborates the immune regulation effect and mechanism of MSC under the stimulation of inflammatory microenvironment.

关 键 词：间质干细胞移植 组织相容性抗原Ⅱ类 系统性炎症反应综合征 缺氧缺血 脑 单核巨噬细胞系统 巨噬细胞极化 T淋巴细胞 调节性 免疫调节 婴儿 新生 

分 类 号：R392[医药卫生—免疫学]