胆固醇酰胺衍生物Langmuir复合膜自组装与纳米结构研究  

Interfacial self-assembly and nanostructure of Langmuir composite films via cholesterol amide derivative

作　　者：贺颖 王昭颖 余旭东[3] 饶砚迪 李景红[1,2] 佟琦 焦体峰[1,2] HE Ying;WANG Zhaoying;YU Xudong;RAO Yandi;LI Jinghong;TONG Qi;JIAO Tifeng(School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China;Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao, Hebei 066004, China;College of Science, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, China)

机构地区：[1]燕山大学环境与化学工程学院,河北秦皇岛066004 [2]燕山大学河北省应用化学重点实验室,河北秦皇岛066004 [3]河北科技大学理学院,河北石家庄050018

出　　处：《燕山大学学报》2019年第5期442-448,共7页Journal of Yanshan University

基　　金：国家自然科学基金资助项目(21872119);河北省青年拔尖人才支持计划资助项目

摘　　要：胆固醇作为一种有机小分子结构单元,广泛应用于两亲分子自组装领域。本研究主要利用了两种胆固醇酰胺衍生物(CH-1、CH-2)分子,以纯水为亚相通过气液界面组装成功制备了Langmuir膜,由表面压力-分子面积等温线表征界面铺展行为,采用原子力显微镜(AFM)对单层Langmuir膜的形貌进行了表征,进一步通过紫外光谱(UV-Vis)、傅里叶红外光谱(FT-IR)、透射电镜(TEM)、扫描电镜(SEM)研究CH-1及CH-2分子制备的多层Langmuir膜界面光谱表征及界面组装过程。实验结果表明,CH-1、CH-2分子在纯水亚相表面形成稳定的Langmuir膜,同时由于CH-2分子在CH-1分子的基础上发生取代效应,从而使两种分子产生不同的组装行为。因此,本研究工作为胆固醇衍生物界面自组装及其纳米结构的相关研究提供了新的思路。As a small organic molecular structural unit, cholesterol is widely used in the self-assembly of amphiphilic molecules. In this study, two kinds of cholesterol derivatives (CH-1, CH-2) are mainly used. The Langmuir films are successfully prepared by gas-liquid interface assembly with pure water as the subphase. The interfacial spreading behavior is characterized by surface pressure-molecular area isotherm. The morphology of monolayer Langmuir films was characterized by atomic force microscope (AFM). Furthermore, the interfacial spectrum characterization and interfacial assembly process of Langmuir films prepared by CH-1 and CH-2 molecules are studied by ultraviolet visible absorption spectrum (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The experiment revealed that CH-1 and CH-2 molecules form stable Langmuir films on the surface of pure water subphase. When the CH-2 molecule is obtained by substitution effect on the basis of the CH-1 molecule, these molecules produced different assembly behavious. Therefore, this work provides a new exploration for the interface self-assembly of cholesterol derivatives and related research on nanostructures.

关 键 词：LB膜 界面组装 胆固醇衍生物 取代效应 纳米结构 

分 类 号：O647.32[理学—物理化学]