前蛋白转化酶枯草溶菌素9致动脉粥样硬化的机制研究进展  

Mechanism of PCSK9-induced Atherosclerosis

作　　者：乐健 何胜虎[1] YUE Jian;HE Shenghu(Department of Cardiology, Northern Jiangsu People s Hospital,Yangzhou 225001, Jiangsu, China;Dalian Medical University, Dalian 116044, Liaoning, China)

机构地区：[1]江苏省苏北人民医院心内科,江苏扬州225001 [2]大连医科大学,辽宁大连116044

出　　处：《心血管病学进展》2019年第7期1000-1003,共4页Advances in Cardiovascular Diseases

基　　金：江苏省卫生厅科研基金面上项目(H201354)

摘　　要：动脉粥样硬化是一种侵入血管壁的慢性炎症性疾病,目前研究表明前蛋白转化酶枯草溶菌素9具有抗动脉粥样硬化的能力,除了常规途径,还可能存在前蛋白转化酶枯草溶菌素9抗动脉粥样硬化作用的新途径。现着重于综述前蛋白转化酶枯草溶菌素9如何参与动脉粥样硬化的形成,并重点描述免疫调节机制在前蛋白转化酶枯草溶菌素9抗动脉粥样硬化中的关键作用。Atherosclerosis is a chronic inflammatory disease that invades the blood vessel wall. Current studies have shown that proprotein convertase subtilisin/kexin type 9(PCSK9) has anti-atherosclerotic ability, and in addition to conventional routes, there may be a new way of anti-atherosclerosis effect of PCSK9. This review focuses on how PCSK9 is involved in the formation of atherosclerosis and focuses on the key role of immune regulatory mechanisms in the anti-atherosclerosis of PCSK9.

关 键 词：前蛋白转化酶枯草溶菌素9 动脉粥样硬化 免疫 

分 类 号：R543.5[医药卫生—心血管疾病]