吗啡注射液致短暂性肌无力1例  

One case of transient muscle weakness caused by morphine injection

作　　者：尹航[1] 于倩[1] 邵丹[1] YIN Hang;YU Qian;SHAO Dan(Department of Pharmacy,China-Japan Union Hospital of Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学中日联谊医院药学部

出　　处：《中国药物应用与监测》2019年第5期322-324,共3页Chinese Journal of Drug Application and Monitoring

基　　金：吉林省食品药品安全监测中心科技项目(2015474)

摘　　要：1例44岁男性患者,既往糖尿病、高血压病病史,因乏力1年,水肿伴胸闷、气短3个月,加重3d入院。入院第14天因胸痛剧烈不缓解给予吗啡注射液(10mg,st,ih)镇痛治疗,约4h后,患者自觉双下肢无力,第2天早上进行性加重至双下肢肌力0级。经过血液透析及营养神经药物治疗后,患者肌力逐渐好转。6d后复查,患者右下肢肌力5级,左下肢肌力3级,且心衰、肺炎、胸腔积液症状好转,予以出院。One 44-year-old male patient with diabetes and hypertension was hospitalized because of fatigue for 1 year, edema with chest tightness and shortness of breath for 3 months and aggravation for 3 days. The patient was treated with morphine injection (10 mg, st, ih) due to unrelieved severe chest pain on the 14th day of admission. About 4 hours later, the patient complained of weakness in both lower limbs which was progressively aggravated. And the patient had the muscle strength grade of level 0 on the second morning. After hemodialysis and nutrient neuropharmaceutical treatment, the patient's muscle strength gradually improved. After 6 days, the patient's muscle strength of the right lower limbs was level 5 and that of the left lower limbs was level 3. The patient was discharged with the simultaneous improvement of heart failure, pneumonia and pleural effusion.

关 键 词：吗啡注射液 短暂性肌无力 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]