ICSI完全受精失败的机制、原因及处理  

Total fertilization failure after intracytoplasmic sperm injection:mechanism,causes and clinical treatment

作　　者：黄学锋[1] 李燕[1] HUANG Xue-feng;LI Yan(Reproductive Medicine Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000)

机构地区：[1]温州医科大学附属第一医院生殖医学中心

出　　处：《生殖医学杂志》2019年第11期1259-1263,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金(81471458)

摘　　要：卵胞浆内单精子注射(ICSI)已广泛用于治疗男性因素不育,但ICSI后完全受精失败(total fertilization failure,TFF)的发生率仍有1%~4%。卵子激活失败(oocyte activation failure,OAF)是ICSI-TTF的主要机制。本文综述了卵母细胞激活的机制、ICSI-TTF的发生机制和原因、OAF的鉴别方法以及相应的处理策略。Intracytoplasmic sperm injection(ICSI)has been widely used to treat male infertility. However,the incidence of total fertilization failure(TFF)after ICSI still remains to be 1% to 4%.The present paper reviews the mechanism of oocyte activation,the mechanism and causes of ICSI-TTF,OAF identification method and the corresponding clinical treatment strategies.

关 键 词：卵胞浆内单精子注射 完全受精失败 卵母细胞激活失败 卵母细胞辅助激活 

分 类 号：R711.6[医药卫生—妇产科学]