经IVF/ICSI治疗后妊娠早期雄激素改变与妊娠结局的相关性研究  

Correlation between maternal testosterone change in early pregnancy and pregnancy outcomes with IVF/ICSI-ET

作　　者：胡平[1,2,3] 陈娟 曹云霞[1,2,3] 徐千花 HU Ping;CHENG Juan;CAO Yun-xia;XU Qian-hua(Reproductive Medicine Center,Department of Obstetrics & Gynecology,the First Affiliated Hospital of Anhui Medical University,Hefei 230000;Anhui Province Key Laboratory of Reproductive Health & Genetics,Hefei 230000;Biopreservation & Artificial Organs,Anhui Provincial Engineering Research Center,Anhui Medical University,Hefei 230000)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖医学中心,合肥230000 [2]安徽医科大学生殖健康与遗传安徽省重点实验室,合肥230000 [3]安徽省生命资源保存与人工器官工程技术研究中心,合肥230000

出　　处：《生殖医学杂志》2019年第11期1278-1282,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金面上项目(81771653)

摘　　要：目的 通过检测行体外受精-胚胎移植(IVF/ICSI-ET)治疗患者妊娠前后血清睾酮(T)水平,研究妊娠早期雄激素改变对妊娠的影响。 方法 收集2015年12月至2017年12月于安徽医科大学第一附属医院生殖中心行IVF/ICSI助孕鲜胚移植后单胎妊娠患者486例。测量母体血清基础T值及移植后30d血清T值,计算妊娠前后T值增长倍数,并随访至分娩或流产,随访内容包括有无早期阴道出血、流产、早产及妊娠期并发症,通过单因素联合多因素相关性分析,观察妊娠后T值改变和妊娠的相关性。 结果 鲜胚移植妊娠早期T值改变与早期阴道出血[aOR1.030,95%CI(0.955,1.121),P>0.05]、流产[aOR0.973,95%CI(0.855,1.325),P>0.05]及早产[aOR1.013,95%CI(0.889,1.145),P>0.05]均无相关,与妊娠期并发症有相关性[aOR1.103,95%CI(1.005,1.211),P<0.05]。 结论 妊娠早期T值改变是IVF/ICSI助孕患者妊娠期并发症的影响因素之一,随着妊娠前后T值增长倍数的升高妊娠期并发症的发生率越高。Objective : To investigate the changes of maternal testosterone (T) in early pregnancy after IVF/ ICSI-ET and the effects on pregnancy outcomes. Methods : A total of 486 pregnant women who conceived with IVF/ICSI and fresh embryo transfer between December 2015 and December 2017 in the Reproductive Medicine Center of the First Affiliated Hospital of Anhui Medical University were recruited in this study.The maternal serum basal T level and the serum T level 30 days after transplantation were measured,and the increase multiple of T level after pregnancy was calculated and followed-up to delivery or miscarriage.The indicators including vaginal bleeding during early pregnancy,miscarriage,premature delivery and complications during pregnancy were followed-up in all the patients.The correlation between the T level change after pregnancy and pregnancy outcome was observed. Results : The T level change in early pregnancy after fresh embryo transplantation was not related to early vaginal bleeding [ aOR 1.030,95% CI (0.955,1.121), P >0.05],miscarriage [ aOR 0.973,95% CI (0.855,1.325), P >0.05] and premature delivery [ aOR 1.013,95% CI (0.889,1.145), P >0.05],but it related to complications during pregnancy [ aOR 1.103,95% CI (1.005,1.211), P <0.05]. Conclusions : The change of T level in early pregnancy is one of the influencing factors of pregnancy complications in IVF/ICSI assisted pregnancy patients.The higher the T level increases before and after pregnancy,the higher the incidence of pregnancy complications.

关 键 词：睾酮 体外受精-胚胎移植 妊娠期并发症 

分 类 号：R711.6[医药卫生—妇产科学]