产气荚膜梭菌VirS/VirR双组分系统调控机制研究进展  

Research progress on regulatory mechanism of the VirS/VirR system in Clostridium perfringens

作　　者：王艳华[1] KHAN MUZ 许笑 蔡建平[1] WANG Yan-hua;KHAN MUZ;XU Xiao;CAI Jian-ping(State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046,China)

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室

出　　处：《中国人兽共患病学报》2019年第10期934-938,956,共6页Chinese Journal of Zoonoses

基　　金：中国农业科学院科技创新工程项目资助(No.CAAS-ASTIP-IVFCAAS)~~

摘　　要：产气荚膜梭菌是一种重要的人兽共患病病原体,该菌引起各种动物坏死性肠炎、肠毒血症、人畜创伤性气性坏疽及人类食物中毒。该菌产生的毒素和酶协同作用导致病变发生。产气荚膜梭菌毒素和酶的产生受到复杂网络调控。VirS/VirR系统是产气荚膜梭菌中最重要也是研究最深入的一个双组分调节系统。本文对这一双组分系统的研究进展进行综述,为进一步阐明该菌的致病机制奠定基础。Clostridium perfringens is an important zoonotic pathogen. Clostridium perfringens causes necrotizing enteritis, enterotoxemia, gas gangrene and food poisoning in humans and livestock, and it produces extracellular enzymes and toxins that are involved in the pathogenesis by complex regulatory network. C. perfringens has a complex regulatory network for toxin and enzyme production. The VirS/VirR system is a most important and best studied two-component regulatory system in C. perfringens . This article reviews the global regulatory system for an in-depth elucidation of the pathogenesis of C. perfringens infections.

关 键 词：产气荚膜梭菌 VirS/VirR系统 调控 

分 类 号：R382.2[医药卫生—医学寄生虫学]