自愈型水凝胶制备原理及应用于组织工程产品中的现状  

The Principle of Self-Healing Hydrogel Preparation and Its Application in Tissue Engineering Products

作　　者：黄元礼[1] 柯林楠[1] 赵丹妹[1] 王春仁[1] Huang Yuanli;Ke Linnan;Zhao Danmei;Wang Chunren(National Institutes for Food and Drug Control,Beijing 102629, China)

机构地区：[1]中国食品药品检定研究院

出　　处：《中国药事》2019年第10期1149-1156,共8页Chinese Pharmaceutical Affairs

摘　　要：目的:考察自愈型水凝胶的生产及应用现状,并探讨其在医疗器械领域的应用前景,为开展下一步的研究工作提供参考。方法:通过查阅近年的文献资料,总结自愈型水凝胶包含的不同结构单元的性质,阐述其实现自愈的原理,以及应用于组织工程产品的研究进展,并对其在生物医药领域的应用进行展望。结果与结论:自愈型水凝胶具有良好的自修复性、可降解性及生物相容性,但力学性能不足等问题限制了其在临床中使用。在未来的研究中,通过对结构改性解决现存问题,自愈型水凝胶会在医疗器械领域中具有很好的应用前景。Objective: To review the current status of the production and application of self-healing hydrogels, discuss the application prospects of self-healing hydrogels in medical devices and to provide references for the further research work. Methods: By reviewing the literature of recent years, authors of the paper summarized the properties of different structural units contained in self-healing hydrogels and explored the principle of selfhealing, the research progress in tissue engineering products as well as the application of self-healing hydrogels in the field of biomedicine. Results and Conclusion: Self-healing hydrogels have good self-healing property, degradability and biocompatibility. However, due to problems like insufficient mechanical properties, self-healing hydrogels were limited in clinical practice. In future research, self-healing hydrogels will have a good application prospect in the field of medical devices by modifying the structure to solve existing problems.

关 键 词：自愈型水凝胶 组织工程 医疗器械 

分 类 号：Q819[生物学—生物工程]