溶致液晶递药系统表征方法的研究进展  

Advances on Characterization of Lyotropic Liquid Crystals as Drug Delivery System

作　　者：储晓琴 田春玲 李争光 蒋建勤[3] 桂双英 CHU Xiao-qin;TIAN Chun-ling;LI Zheng-guang;JIANG Jian-qin;GUI Shuang-ying(Anhui University of Chinese Medicine, Hefei 230012, China;Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China;School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198 , China)

机构地区：[1]安徽中医药大学药学院,合肥230012 [2]安徽省中医药科学院药物制剂研究所,合肥230012 [3]中国药科大学中药学院,南京211198

出　　处：《中国药学杂志》2019年第19期1545-1551,共7页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(818038318,81873019);安徽省高校优秀人才项目资助(gxyq2018025);安徽高校自然科学研究项目资助(KJ2018A0301)

摘　　要：溶致液晶一般是由两亲性脂质高分子材料在极性溶剂中自组装形成的一种胶束缔合,作为一种新型的药物递送载体,研究越来越广泛。目前应用于口服给药、注射给药、皮肤给药、眼部给药、腔道给药(口腔、鼻腔、阴道)等。药用溶致液晶以层状相、反六角相、反立方相见长,不同结构的液晶其内部的分子排列会影响体系内的药物分布、黏度、分子间的相互作用等,进而影响体内外释药行为及药动学特征等,因此对其微观结构的表征至关重要。笔者结合所在课题组对溶致液晶作为递药载体的研究和相关文献,对溶致液晶微观结构的表征方法进行综合阐述,为进一步研究溶致液晶载药系统提供参考。Lyotropic liquid crystal( LLC) is generally a kind of micelle association formed by self-assembly of amphiphilic lipid polymers in polar solvents. It have been applied in the study of drug delivery of administration of oral, skin injection, ocular, and cavity channel routes(including buccal cavity, nasal cavity, vagina), et al. Medical liquid crystal mainly includes lamellar phase, inverse hexagonal phase and inverse cubic phase. Inner assembling order in different structures of liquid crystals will affect the drug localization, viscosity, molecular interactions, and further drug release in vitro and in vivo, pharmacokinetics and so on. Thus, it is very important to characterize their microstructures. In this article, the characterization methods of LLC microstructures are comprehensively described based on the research of LLC as drug delivery carrier and related literatures, which can provide reference for further study of LLC drug delivery system.

关 键 词：溶致液晶 表征 偏光显微镜 小角X射线散射 差式扫描量热法 

分 类 号：R944[医药卫生—药剂学]