VCAM-1与VLA-4相互作用与肿瘤关系的研究进展  

Advances in research on the relationship between VCAM-1 and VLA-4 interactions and tumors

作　　者：李生军 李向茸[1] 冯若飞[1] LI Sheng-jun;LI Xiang-rong;FENG Ruo-fei(Biomedical Research Center;Life Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China)

机构地区：[1]西北民族大学生物医学研究中心,甘肃兰州730030 [2]西北民族大学生命科学与工程学院,甘肃兰州730030

出　　处：《基础医学与临床》2019年第11期1639-1643,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(31460665);教育部“创新团队发展计划”(IRT_17R88);西北民族大学“双一流”引导专项生物工程特色学科(10018703,1001070204)

摘　　要：晚期抗原4(VLA-4)与血管细胞黏附分子1(VCAM-1)互为配体,VLA-4能与VCAM-1的第1结构域或第4结构域的特异性结合。在VCAM-1的结构域1和结构域4中发现的6个线性氨基酸序列对两者的特异性结合起着至关重要的作用。VLA-4和VCAM-1在多种疾病中都高表达并与许多疾病的发病机制有着密不可分的联系。The late antigen 4(VLA-4) and the vascular cell adhesion molecule 1(VCAM-1) are ligands to each other, and the late antigen 4 can specifically bind to the first or the fourth domain of the vascular cell adhesion molecule1,and six linear amino acid sequences found in domain 1 and domain 4 of vascular cell adhesion molecules. This sequence plays a crucial role in the specific binding of the two.Advanced antigen-4 and vascular cell adhesion molecule-1 are highly expressed in many diseases and are inextricably linked to the pathogenesis of many diseases.

关 键 词：VCAM-1 VLA-4 NF-ΚB 肿瘤 

分 类 号：Q74[生物学—分子生物学]