骨代谢生化指标临床应用专家共识(2019)  

Expert consensus on clinical application of biochemical indicators of bone metabolism (2019)

作　　者：张萌萌 张秀珍[2] 邓伟民 张智海[4] 徐辉[5] 葛继荣[6] 王永福[7] 黄宏兴 史晓林 张东伟 毛未贤 马倩倩 高远 郭郡浩 张红红[13] 张晓梅[14] 印平 赵方 晁爱军[17] 张岩[18] 李英华 李毅中[20] 赵国阳[21] 董红宇[22] 吴岩[23] 吴涤 邹军[25] 周惠琼 ZHANG Mengmeng;ZHANG Xiuzhen;DENG Weimin;ZHANG Zhihai;XU Hui;GE Jirong;WANG Yongfu;HUANG Hongxing;SHI Xiaolin;ZHANG Dongwei;MAO Weixian;MA Qianqian;GAO Yuan;GUO Junhao;ZHANG Honghong;ZHANG Xiaomei;YIN Ping;ZHAO Fang;ZHAO Aijun;ZHANG Yan;LI Yinghua;LI Yizhong;ZHAO Guoyang;DONG Hongyu;WU Yan;WU Di;ZOU Jun;ZHOU Huiqiong(Chinese Journal of Osteoporosis,Beijing 100102;Diabetes Research Center,Beijing University of Chinese Medicine,Beijing 100029;FAW General Hospital of Jilin Province,Changchun 130011;General Hospital of Eastern Theater of the COMMAND,Nanjing 210002;PL A General Hospital,Beijing 100853;Peking University International Hospital,Beijing 102206;Jinshan Hospital Affiliated to Dalian Medical University,Benxi 117000;Jinqiu Hospital of Liaoning Province,Shenyang 110016;Tianjin Hospital,Tianjin 300211;Longhua Hospital Affiliated to Shanghai University of Chinese Medicine,Shanghai 200003;The fifth People's Hospital of Shanghai,Shanghai 200240;Tongji Hospital affiliated Tongji University,Shanghai 200065;The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000;AffiliatedHospital of Jiangsu University,Zhenjiang 212000;Shijingshan Hospital,Capital Medical University,Beijing 100043;Inner Mongolia Medical University,Hohhot 010110;Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040;Shanghai University of Sport,Shanghai 200438;The Fourth Medical Center of General Hospital of the Chinese People's Liberation Army,Beijing 100037,China;General Hospital of Southern Theater of the COMMAND,Guangzhou 510010;Aviation General Hospital,Beijing 100012;Jilin University,Changchun 130012;Fujian Academy of Chinese Medicine,Fuzhou 350003;The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010;The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510240;The Second Affiliated Hospital of Zhejiang University of Chinese Medicine,Hangzhou 310005)

机构地区：[1]《中国骨质疏松杂志》社,北京100102 [10]北京中医药大学糖尿病研究中心,北京100029 [11]吉林省一汽总医院,吉林长春130011 [12]中国人民解放军东部战区总医院,江苏南京210002 [13]解放军总医院,北京100853 [14]北京大学国际医院,北京102206 [15]大连医科大学附属金山医院,辽宁本溪117000 [16]辽宁省金秋医院,辽宁沈阳110016 [17]天津医院,天津300211 [18]上海中医药大学附属龙华医院,上海200003 [19]上海市第五人民医院,上海200240 [2]同济大学附属同济医院,上海200065 [20]福建医科大学附属第二医院,福建泉州362000 [21]江苏大学附属医院,江苏镇江212000 [22]首都医科大学北京市石景山医院,北京100043 [23]内蒙古医科大学,内蒙古呼和浩特010110 [24]内蒙古科技大学包头医学院,内蒙古包头014040 [25]上海体育学院,上海200438 [26]中国人民解放军总医院第四医学中心,北京100037 [3]中国人民解放军南部战区总医院,广东广州510010 [4]航空总医院,北京100012 [5]吉林大学,吉林长春130012 [6]福建省中医药研究院,福建福州350003 [7]内蒙古科技大学包头医学院第一附属医院,内蒙古包头014010 [8]广州中医药大学第三附属医院,广东广州510240 [9]浙江中医药大学附属第二医院,浙江杭州310005

出　　处：《中国骨质疏松杂志》2019年第10期1357-1372,共16页Chinese Journal of Osteoporosis

摘　　要：骨代谢生化指标包括钙磷代谢调节指标、骨形成标志物、骨吸收标志物、激素与细胞因子。骨代谢生化指标分别来源于骨、软骨、软组织、皮肤、肝、肾、小肠、血液及内分泌腺体等,是由成骨细胞或破骨细胞分泌的酶和激素,以及骨基质的胶原蛋白代谢产物或非胶原蛋白。骨代谢生化指标可及时反映骨转换状态,灵敏度高、特异性强,用于骨质疏松诊断分型、预测骨折风险、抗骨质疏松治疗疗效评价,以及代谢性骨病的鉴别诊断。并且在骨质疏松流行病学、发病机制、骨质疏松药物的研究方面具有重要的临床意义。The bone metabolism biochemical markers included calcium and phosphorus metabolism indicators, bone formation markers, bone resorption markers, hormone and cytokine. The bone metabolism biochemical markers were derived from the bone, cartilage, soft tissue, skin, liver, kidney, small intestine, blood, endocrine glands, and so on. They were enzymes and hormones secreted by osteoblasts or osteoclasts, and the product or non-collagen proteins of metabolic bone collagen matrix. The bone metabolism biochemical markers could reflect the state of bone turnover promptly, with high sensitivity and specificity, it had been used in osteoporosis diagnosis, prediction of fracture risk, curative effect observation of drug treatment, and the differential diagnosis of metabolic bone disease. And it had important clinical significance in epidemiology, pathogenesis and drug research of osteoporosis.

关 键 词：骨代谢 钙磷代谢调节指标 骨形成标志物 骨吸收标志物 激素 细胞因子 

分 类 号：R336[医药卫生—人体生理学]