2型糖尿病患者血清Betatrophin水平与骨密度的相关性研究  

Study of the relationship between bone mineral density and betatrophin levels in patients with type 2 diabetes mellitus

作　　者：徐梦娇 李昊翔 于淑萍[1] 袁婧 丁艺 袁国跃[1] 王东[1] 尹卫[1] 陈圣杰[1] 杨玲[1] XU Mengjiao;LI Haoxiang;YU Shuping;YUAN Jing;DING Yi;YUAN Guoyue;WANG Dong;YIN Wei;CHEN Shengjie;YANG Ling(Department of Endocrinology,Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属医院内分泌代谢科

出　　处：《中国骨质疏松杂志》2019年第10期1378-1381,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81570721,81370965);江苏省高层次卫生人才“六个一工程”(LGY2016053);江苏省“六大人才高峰”第十二批高层次人才项目(2015-WSN-006);苏州卫生职业技术学院立项课题(Swhy201604)

摘　　要：目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清Betatrophin水平与骨密度(bone mineral density,BMD)的相关性。方法选择95例T2DM患者,采用双能X线骨密度仪检测所有患者腰椎1~4(L1-L4)、股骨颈(femoral neck,FN)及全髋(total hip,TH)部位BMD,按BMD将患者分为骨量正常组(n=46)及骨量异常组(包括骨量减少及骨质疏松,n=49)。所有患者均行口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)及胰岛素释放试验。血清Betatrophin水平用酶联免疫吸附法进行检测。结果与BMD正常组相比,BMD异常组血清Betatrophin水平显著增高(P <0. 05)。相关分析显示,Betatrophin与FN、TH两个部位骨密度呈负相关(r=-0. 238、-0. 208,P均<0. 05)。根据血清Betatrophin水平由低到高分为3组,BMD异常在3组中的发生率逐渐升高(38. 7%、53. 1%及62. 5%)。结论 T2DM骨密度异常患者血清Betatrophin水平显著升高,提示Betatrophin可能在糖尿病骨质疏松症的发生发展中发挥作用,对该指标进行检测可为糖尿病骨质疏松症的预防和治疗提供新的临床依据。Objective To investigate the relationship between bone mineral density(BMD) and betatrophin in patients with type 2 diabetes mellitus(T2 DM). Methods We enrolled 95 patients with T2 DM. BMD of the lumbar vertebrae(L1-L4), femoral neck(FN), and total hip(TH) in all the patients were measured using dual energy X-ray absorptiometry. According to BMD values, subjects were divided into normal bone mass group(n=46) and abnormal bone mass group(including low bone mass and osteoporosis, n=49). Oral glucose tolerance test(OGTT) and insulin releasing test were conducted in all the patients. Serum betatrophin levels were determined with ELISA method. Results Compared with normal bone mass group, the levels of serum betatrophin in abnormal bone mass group was significantly elevated(P<0.05). Based on the correlation analysis, the levels of serum betatrophin was negatively correlated with BMD of FN and TH(r=-0.238,-0.208, respectively, all P<0.05). When subjects were divided into three subgroups from low to high betatrophin levels, there was an increase in abnormal BMD rates(38.7%, 53.1% and 62.5%). Conclusion Serum betatrophin could be an indicator in the occurrence and development of osteoporosis in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 Betatrophin 骨密度 骨质疏松 

分 类 号：R587.1[医药卫生—内分泌]