氧化应激对骨重建的影响  

Oxidative stress in bone remodeling

作　　者：程韶 舒冰[1,2,3] 赵永见 王晶[1,2,3] 赵世天 陶渝仁[1,2,3] 杨骏杰[1,2,3] 张伟强 卢盛 王拥军 CHENG Shao;SHU Bing;ZHAO Yongjian;WANG Jing;ZHAO Shitian;TAO Yuren;YANG Junjie;ZHANG Weiqiang;LU Sheng;WANG Yongjun(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Spine Institute,Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education of China,Shanghai 200032;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学脊柱病研究所,上海200032 [3]教育部重点实验室(筋骨理论与治法),上海200032 [4]上海中医药大学,上海201203

出　　处：《中国骨质疏松杂志》2019年第10期1478-1482,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81673991,81730107);国家重点研发计划(2018YFC1704300);科技部重点领域创新团队项目(2015RA4002);教育部创新团队发展计划(IRT1270);上海市重中之重临床医学中心建设项目(2017ZZ01010);上海市三年行动计划(ZY(2018-2020)-CCCX-3003);上海中医药大学杏林学者项目;上海中医药大学研究生创新培养专项(Y201910)

摘　　要：骨形成和骨吸收之间的协调平衡共同维持着骨重建的稳态。由于衰老、雌激素缺乏等因素引起体内氧化体系与抗氧化体系之间的平衡被打破,导致活性氧生成增多,发生氧化应激。近年来的研究发现活性氧所引起的氧化应激反应对骨重建过程中的骨形成和骨吸收均有重要的影响,机体内积累产生的过多活性氧通过对细胞因子、酶活性以及信号通路的调节,干预核内基因的转录表达,最终导致骨髓间充质干细胞、成骨细胞、骨细胞和破骨细胞增殖凋亡或分化功能的异常,使骨重建失衡,形成以骨吸收为主的代谢性骨病,从而引起骨质疏松症。因此,笔者就近年来氧化应激的产生及氧化应激对骨髓间充质干细胞、成骨细胞、骨细胞、破骨细胞的影响,骨质疏松症的抗氧化治疗等方面作一综述,对进一步认识氧化应激在骨重建中的生理病理学机制有着重要意义。The balance between bone formation and bone resorption maintains the homeostasis of bone remodeling. Aging, estrogen deficiency and other factors lead to the imbalance between the oxidation system and antioxidant system in the body, Resultsing in increased production of reactive oxygen species and oxidative stress. Recent studies have found that oxidative stress induced by reactive oxygen species plays an important role in bone formation and absorption during bone remodeling. Excessive reactive oxygen species affects the nuclear gene transcriptions through regulation of the cytokine expressions, enzyme activity and related signaling pathways, leading to the proliferative and functional abnormalities of bone marrow mesenchymal stem cells, osteoblasts, osteocytes and osteoclasts. The imbalanced bone remodeling may lead to metabolic bone diseases including osteoporosis. Therefore, this article summarized the sources of oxidative stress and its effects on bone marrow mesenchymal stem cells, osteoblasts, osteocytes and osteoclasts as well as the anti-oxidative treatment of osteoporosis in recent years, which is of great significance to further understand the physiological and pathological mechanism of oxidative stress in bone remodeling.

关 键 词：氧化应激 骨重建 骨质疏松 骨髓间充质干细胞 成骨细胞 骨细胞 破骨细胞 

分 类 号：R681[医药卫生—骨科学]