排石灵对肾结石的影响及其利尿、抗炎、镇痛作用  

Influence of Pai Shi Ling (PSL) on the experimental kidney stone and its diuretic,anti-inflammatory and analgesic effects

作　　者：吴琳华[1] 刘红梅[1] 李涛[1] 郭守利[1] 张怡[2] 

机构地区：[1]哈尔滨医科大学附属二院临床药学药物研究所,哈尔滨150086 [2]解放军211医院,哈尔滨150080

出　　处：《中国新药杂志》2002年第8期608-611,共4页Chinese Journal of New Drugs

基　　金：黑龙江省自然科学基金项目 (D993 8)

摘　　要：目的 :研究排石灵对肾结石的影响及其利尿、抗炎和镇痛作用。方法 :制备大鼠实验性肾结石模型 ,分别预防和治疗给药 ,测定肾钙含量观察肾脏的病理改变。对水负荷大鼠给予排石灵 ,观察其利尿作用。对角叉菜胶导致的大鼠足跖肿胀炎症模型给予排石灵 ,观察其抗炎效果。采用冰醋酸扭体法观察排石灵对疼痛的缓解作用。结果 :排石灵剂量为 1.3和 2 .6 g·kg- 1 时可明显抑制大鼠实验性草酸钙肾结石的形成 ,并能促进结石的排出 ,与对照组比较 ,差异有统计学意义。排石灵对水负荷大鼠有持久的利尿作用。抑制角叉菜胶导致的大鼠足跖肿胀 ,抑制冰醋酸引起的小鼠腹痛。结论 :排石灵对大鼠实验性肾结石的预防和治疗具有良好的作用。Objectives:To study the influence of Pai Shi Ling (PSL) on kidney stone and observe its diuretic,anti inflammatory and analgesic effects.Methods:To determine the calcium content and to observe its pathological change of kidney after the experimental model rats were given PSL.To research the diuretic effects after PSL was given to water loaded rats and to observe the anti inflammatory action and analgesic effects to the plantar plumping rats caused by carrageen and mice in analgesia caused by glacial acetic acid.Results:PSL can obviously inhibit the formation of experimental calcium oxalate monohydrate crystal in kidney and promote the elimination of kidney stone in rats.There were significant differences between the PSL group and the control group.PSL had lasting diuretic effects on water loaded rats and can release the abdominal pain caused by glacial acetic acid in mice and inhibited the swelling of rat toe caused by carrageen.Conclusion:PSL had good effects on prevention and treatment of experimental kidney stone in rats.

关 键 词：排石灵 肾结石 利尿 抗炎 镇痛 中医药疗法 药理 

分 类 号：R277.524[医药卫生—中医学]