异福酰胺胶囊溶出度测定方法  

Determination of dissolution of rifampin in Yifuxian'an capsules

作　　者：陈宁[1] 周学敏[1] 徐斌[1] 张勤[1] 薛玉英[1] 

机构地区：[1]江苏省药物研究所,南京210009

出　　处：《中国新药杂志》2002年第8期615-617,共3页Chinese Journal of New Drugs

摘　　要：目的 :建立复方制剂异福酰胺胶囊中利福平溶出度测定方法。方法 :以紫外 可见分光光度法测定难溶性成分利福平的溶出量作为异福酰胺胶囊溶出度测定指标。结果 :该方法测得利福平平均回收率为 98.90 % ,RSD为 0 .6 6 %。结论 :该方法辅料及异烟肼、吡嗪酰胺无干扰 ,方法简捷 ,结果准确。Objective:To establish a method in determining the dissolution of the rifampin and isoniazid and pyrazinamide capsules(Yifuxian'an capsules).Methods:UV visible spectrophotometry was adopted to determine the dissolution of rifampin,which marked the dissolution of that capsule.Results:An average recovery of 98.90% was obtained with a RSD of 0.66%.Conclusion:This simple,rapid and accurate method provides a reliable dissolution determination for the Yifuxian'an capsules.\;

关 键 词：利福平 溶出度 反相高效液相色谱法 紫外-可见分光光度法 

分 类 号：R978.3[医药卫生—药品]