海带素(FGS)对高胆固醇血症小鼠血清胆固醇的调节作用  

Study on the serum cholesterol regulation of FGS from Lamina- ria japonica Aresch

作　　者：曲爱琴[1] 王琪琳[1] 张英慧[1] 李守玲[1] 王海仁[1] 吕辉 

机构地区：[1]山东大学生命科学院,山东济南250100 [2]中原油田医院,河南濮阳457001

出　　处：《中国海洋药物》2002年第5期31-33,共3页Chinese Journal of Marine Drugs

基　　金：国家"九五"攻关项目(项目编号:96-C01-05-02)

摘　　要：以实验型高胆固醇血症小鼠为模型,每天用250、750及1500mg·kg-1的海带素（FGS）灌胃高胆固醇血症小鼠,分别在第10、20、30和40天测定血清胆固醇含量,结果表明:第40天Ⅰ、Ⅱ、Ⅲ实验组的TC比对照组分别降低37.6、54.2、66.2mg·dL-1,LDL-C比对照组分别降低47.6、86.6、94.4mg·dL-1,HDL-C比对照组分别升高16.1、38.2、36.7mg·dL-1,说明海带素能有效地调节血清胆固醇水平。The hypercholesterolemia model was established by feeding mice on hypercholester-ol diet. FGS was administered to the hypercholesterolemia mice at the dose of 250,750 and 1500mg · kg-1 ·d-1, respectively. On the 10,20,30 and 40th day, the serum cholesterol was determined. The results were as follows: 40th day the concentration of TC(Ⅰ,Ⅱ,Ⅲ) was 37. 6,54. 2 and 66. 2mg ·dL-1 lower than that of the control group; and the cocentration of LDL-C was 47. 6,86. 6 and 94. 4mg ·dL-1 lower than that of the control group; while the concentration of HDL-C was 16. 1,38. 2 and 36. 7mg·dL-1 higher than that of the control group. It was proved that FGS was an effective serum cholesterol regulator.

关 键 词：高胆固醇血症 调节作用 海带素 血清胆固醇 药理 

分 类 号：R282.77[医药卫生—中药学]