海狗肾抗衰老作用的实验研究  

Experimental Studies on Antiaging Effects of Seal Kidney

作　　者：王静凤[1] 田树川[1] 贾钢锐[2] 

机构地区：[1]青岛海洋大学,山东青岛266003 [2]解放军401医院,山东青岛266071

出　　处：《中国海洋药物》2002年第5期34-36,共3页Chinese Journal of Marine Drugs

摘　　要：目的:研究海狗肾对雄性老龄大鼠的抗衰老作用。方法:以环磷酰胺造成雄性大鼠生殖系统受损模型,灌胃海狗肾30d后,测定血清睾酮含量,血清SOD活性和MDA含量;采用石蜡包埋,H-E染色的方法,光镜下观察辜九的组织学变化。结果:海狗肾能够显著提高正常大鼠和生殖系统受损模型大鼠的血清睾酮含量,改善其睾丸间质细胞的功能状态,促进精子的发生与发育;显著提高血清SOD活力,降低血清MDA含量。结论:海狗肾具有显著的抗衰老作用。Objective Antiaging effects of seal kidney on aged male rats have been studies. Methods: Reproduction system of male rat was damaged by CYP. After ig. seal kidney 30 days, the content of serum T, serum MDA and the activity of SOD were determined. The changes of histology of the testis were observed by microscope with the method of paraffin embedding and H-E staining. Results The contents of serum T not only in normal rat but also in reproduction system damaged rat were markedly enhanced. The function condition of leydig's cells in the testis was improved. The formation and development of spermatozoon were increased. The activity of serum SOD was remarkably raised , while the content of serum MDA was strikingly reduced. Conclusion Seal kidney has the notable antiaging effects.

关 键 词：实验研究 海狗肾 抗衰老 血清睾丸酮 丙二醛 超氧化物歧化酶 曲细精管 间质细胞 

分 类 号：R282.77[医药卫生—中药学]