乌贼墨对小鼠NK细胞杀伤活性的影响和抑瘤作用的研究  

Studies of sepia influence on NK cells activity and effect on in- hibition tumor in mice

作　　者：赫甡[1] 谢光麟[1] 赫明昌[1] 

机构地区：[1]中国医科大学基础医学院,辽宁沈阳110001

出　　处：《中国海洋药物》2002年第5期37-39,共3页Chinese Journal of Marine Drugs

摘　　要：研究乌贼墨对小鼠脾细胞NK细胞杀伤活性的诱生作用及NK细胞杀伤活性的持续时间,并探讨乌贼墨对荷瘤鼠脾细胞NK细胞杀伤活性的影响及抑制肿瘤生长的作用。用5％的乌贼墨给小鼠灌胃,连续5d后取不同时间的小鼠脾细胞,应用乳酸脱氢酶释放法检测NK细胞杀伤活性。结果表明:口服乌贼墨后可使小鼠NK细胞杀伤活性增强,实验组与对照组比较有显著性差异（P<0.01）;诱生后24h杀伤活性明显增强,2周左右恢复正常水平。乌贼墨可使荷瘤鼠NK细胞杀伤活性增强,瘤体明显小于阴性对照组,病理学分析证明小鼠瘤组织出血坏死及炎细胞浸润程度明显高于对照组,阳性对照组小鼠免疫功能损伤严重。Study on sepia effect on NK cells killing activity and inhibit tumor growth in the load tumor mice, normal and load tumor mice were poured into sepia through mouth, examining on activity of NK cells and lasted time of it . Through pathological diagnosis of tumor tissues and NK cells killing activity for load tumor mice judge effect on sepia . The results showed that the sepia can increase spleen cells function of natural killer cells and it can last 7 days , and prompt tumor tissues large area necrosis and inflammatory cells infiltration. To compared them with control groups, it is obvious that the sepia can inhibit tumor growth and to increase activity of NK cells.

关 键 词：乌贼墨 NK细胞 脾细胞 活性 荷瘤 药理 

分 类 号：R282.77[医药卫生—中药学]