ⅢB族金属苯乙酰缩氨基硫脲配合物的合成、表征与抗肿瘤活性  

Preparation,Characterization and Antitumor Activity of Sc(Ⅲ),Y(Ⅲ) and La(Ⅲ) Complexes of Acetophenone Thiosemicarbazone

作　　者：唐慧安[1] 王流芳[2] 赵恺寅[1] 

机构地区：[1]天水师范学院化学系,甘肃天水741018 [2]兰州大学化学系及应用有机国有重点实验室,甘肃兰州730000

出　　处：《稀土》2002年第5期14-17,共4页Chinese Rare Earths

基　　金：国家自然科学基金项目 (2 95 710 13 )

摘　　要：合成了 Sc( )、Y ( )、L a( )与苯乙酰缩氨基硫脲形成的 1∶ 2型配合物。元素分析确定其分子式为 :ML2 Cl· n H2 O[M=Sc( ) ,Y( ) ,L a( ) ,n=0～ 5 ],用红外光谱、紫外光谱、核磁共振氢谱对该配合物进行了结构表征 ,研究了其摩尔电导和溶解性能 ,并测试了其抗肿瘤活性。In this paper three complexes of Sc(Ⅲ),Y(Ⅲ), La(Ⅲ) with acetophenone thiosemicarzone were prepared The elementary analyses revealed that the formula of the complexes was ML 2Cl·nH 2O[M= Sc(Ⅲ),Y(Ⅲ), La(Ⅲ),n=0~5] The structure of the complexes was characterized by IR,UV,H'NMR,DTA-TGA and the molecular conductance Afterwards,the antitumor activity of the complex of Y(Ⅲ) was tested

关 键 词：ⅢB族金属 表征 合成 苯乙酰缩氨基硫脲 配合物 抗肿瘤活性 结构 

分 类 号：R979.1[医药卫生—药品] R914[医药卫生—药学]