对20种抗肿瘤药物的致突变性研究  

A STUDY ON THE MUTAGENICITY OF 20 ANTINEOPLASTIC DRUGS

作　　者：赵泽贞[1] 温登瑰[1] 魏丽珍[1] 朱惠民[2] 赵文元[2] 赵永良[2] 高优真[2] 

机构地区：[1]河北医学院环境卫生教研室,石家庄050011 [2]河北省肿瘤研究所

出　　处：《癌变．畸变．突变》1992年第5期42-44,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文报告用噬菌体诱导试验对20种抗肿瘤药物的致突变性进行筛选,并用Ames试验、SOS固体显色试验和噬菌体诱导试验3种方法联合测试其中11种药物的致突变性,各种试验方法均做加和不加大鼠肝脏微粒体酶代谢活化系统(S9)的两种试验。结果15种药物有致突变作用,阳性率为75％。三种试验方法联合检测的符合率为72.73％。This paper investigated the mutagenic effects induced by 20 antineoplastic chemical drugs with the SOS inductest, SOS chromotest and Ames assay. The results indicated that 15 of the 20 (75%) chemical drugs could induce mutations in the test strains, no matter S9 (rat liver microsomal enzymes) were present or not. The three tests yielded an agreement rate of 72. 73%.

关 键 词：抗癌药 致突变 

分 类 号：R979.1[医药卫生—药品]