乙氧乙醇乙酯和乙氧乙醇的代谢与选择性发育毒性的研究  

STUDY ON THE METABOLISM AND EXPRESSED SELECTIVEDEVE LOPMENTAL TOXICITIES OF EEA AND EE

作　　者：王彦泓[1] L.M.Newmanand E.M.Johnson 

机构地区：[1]天津市计划生育研究所,天津300191 [2]美国费城杰佛逊医学院

出　　处：《癌变．畸变．突变》1992年第6期18-22,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：用大鼠和家兔生殖毒性一代三段试验中的第二段致畸试验(以下简称Ⅱ段试验)和水螅试验评价乙氧乙醇乙酯(EEA)和乙氧乙醇(EE)的选择性发育毒性时,得到不同的结果。为探讨引起差异的可能原因,测定了参与这组化合物代谢的酯酶(CE)和醇脱氢酶(ADH)活性,以综合分析试验结果。大鼠试验结果表明EEA和EE均有选择性发育毒性,其A/D分别是4和3.8,家兔试验结果表明EEA有选择性发育毒性,而EE则无,A/D分别是4和1,水螅试验结果表明EEA无选择性发育毒性,而EE有,共A/D分别是1和5,因家兔的CE无转化EEA活性,故毒性表达与大鼠不同;水螅缺乏转化EEA的CE活性,且有其它酶活性,因此毒性反应也与大鼠不尽相同。结论认为代谢系统不同可导致同种物质对不同种属个体的发育毒性不同。To find out the possible cause that brought about the differences of expressed Selective developmental toxicities in rat, rabbit and hydra when reproductive, toxicities of EEA (ethoxyethanol acetate)and EE(ethoxyethanol)were evaluated in rat and rabbit segment II experiment and Hydra Assay, the three test results were put together and analyzed. And esterase(CE)and alcohol dehydrogenase(ADH) activities that thought to be important in the metabolism of EEA and EE werealso determined. In rat segment II experiment, EEA and EE expressed selective developmental toxicities, the A/D ratio were 4 and 3.8 respectively. In rabbit segment II experiment, EEA had selective developmental toxicity and EE had not, the A/D ratio were 4 and 1 respectively.In Hydra Assay, EEA had not selective developmental toxicity and EE had, the A/D ratio were 1 and 5 respectively. The expressed selective developmental toxicity in rabbit was different from that in rat, because rabbit could not convert EEA to EE. Hydra had not CE, but had ADH, so hydra test result was also dofferent from the rat test result. Conclusion: different metabolism pathway caused different selective developmental toxicity of the same chemical in the three kinds of animals, rat, rabbit and hydra.

关 键 词：EEA 乙氧乙醇 选择性发育 毒性 

分 类 号：R996[医药卫生—毒理学]