牛流行热病毒灭活疫苗免疫后牛外周血淋巴细胞亚类分布的研究  

Detection of T Cell Subpopulations in Bovine Peripheral Blood Lymphocytes after Immunized with the Inactivated Viral Vaccine

作　　者：金红[1] 李媛[1] 宋晓华[1] 孟庆文[1] 吴东来[1] 于康震[1] 刘保全[2] 严隽端[1] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室,黑龙江哈尔滨150001 [2]东北农业大学

出　　处：《中国预防兽医学报》2002年第6期449-452,共4页Chinese Journal of Preventive Veterinary Medicine

摘　　要：对牛流行热病毒灭活疫苗免疫并攻毒后 ,牛外周血淋巴细胞亚类的变化进行了研究。结果表明 ,灭活苗免疫后 ,牛的CD4 + 显著升高 ,可能与参与辅助B淋巴细胞合成抗体有关 ,攻毒后 ,γδT细胞均显著上升 ,免疫组在攻毒后 3周仍保持在相当的高水平 ,IL_2Rα阳性细胞在攻毒后高热期也有显著升高 ,而CD8+ 细胞没有明显变化。PBLs were collected from cattle after immunized with the inactivated viral vaccine.The distributions of T cell subpopulations in bovine PBLs were detected.The results showed that CD4 +would rise rapidly and might play an important role in response to challenge.CD8 +remained comparably calm.γδT cell and IL_2R did not change variable,but went up quickly after challenged.

关 键 词：牛流行热病毒 外周血淋巴细胞亚类 病毒灭活疫苗 分布 牛 免疫接种 

分 类 号：S858.23[农业科学—临床兽医学] S852.4[农业科学—兽医学]