Effect of Moniliformin on Myocardial Contractility in Rats  

作　　者：FANLILI LIJUAN 等 

机构地区：[1]InstituteofMateriaMedica,ChineseAcademyofMedicalSciences，1XianNongTanStreet,Beijing100050 [2]Instituteo

出　　处：《Biomedical and Environmental Sciences》1991年第3期290-294,共5页生物医学与环境科学（英文版）

摘　　要：The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10~(-7 mol/liter in isolated heart decreased myocardial contractile force by 52±17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased ±LV dP/dt max by 52± 6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10~(-7 mol/liter in isolated heart decreased myocardial contractile force by 52±17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased ±LV dP/dt max by 52± 6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.

分 类 号：R965[医药卫生—药理学]