Role of Exogenous Reduced Glutathione on Time Dependent ^(203)Hg Distribution in Liver and Kidney of a Freshwater Teleost, Anabas testudineus  

作　　者：DEBAPRIYA SARKAR DERAPRASAD DAS AND SHELLEY BHATTACHARYA (Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan 731235, India) 

出　　处：《Biomedical and Environmental Sciences》1997年第1期60-64,共5页生物医学与环境科学（英文版）

摘　　要：Time-dependent tissue distribution of mercury(Hg) was studied in a freshwater perch,Anabas testudineus which revealed that the liver and kidneys are the major sites of Hg reten tion. The role of reduced glutathione (GSH) in the clearance of Hg was also investigated to e valuate the ameliorative effect of this nucleophile. For this purpose, the perch was given GSH 15 min before or after they received 203Hg by injection. The fish were then sacrificed at 24 h and 48 h later. The results clearly indicate that exogenous GSH can significantly reduce Hg retention in both the liver and kidneys, demonstrating a direct role of this nucleophile in the amelioration of Hg-induced toxicity in the early phase of intoxicationTime-dependent tissue distribution of mercury(Hg) was studied in a freshwater perch,Anabas testudineus which revealed that the liver and kidneys are the major sites of Hg reten tion. The role of reduced glutathione (GSH) in the clearance of Hg was also investigated to e valuate the ameliorative effect of this nucleophile. For this purpose, the perch was given GSH 15 min before or after they received 203Hg by injection. The fish were then sacrificed at 24 h and 48 h later. The results clearly indicate that exogenous GSH can significantly reduce Hg retention in both the liver and kidneys, demonstrating a direct role of this nucleophile in the amelioration of Hg-induced toxicity in the early phase of intoxication

关 键 词：Hg Distribution in Liver and Kidney of a Freshwater Teleost Anabas testudineus Role of Exogenous Reduced Glutathione on Time Dependent 

分 类 号：R995[医药卫生—毒理学]