白花蛇舌草对宫颈癌细胞钙信号的影响  

Influence of Spreading Hedyotis Herb on Calcium Beaconage of Cervix Cancer Cells

作　　者：高冬[1] 高永琳[2] 白平[1] 刘如玉[1] 

机构地区：[1]福建中医学院现代医学部,福建福州350003 [2]福建医科大学生化与分子生物学系,福建福州350004

出　　处：《福建中医学院学报》2002年第4期37-39,共3页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省卫生厅青年基金资助项目 (3 2 0 2 -1980 2 1)

摘　　要：为探讨白花蛇舌草对宫颈癌细胞胞内游离钙浓度的影响及其抗癌作用机理。利用荧光染料 Fura-2在细胞内能与游离钙结合 ,在一定波长光的激发下可发出荧光的特性 ,根据荧光的强度来检测游离钙的变化。结果显示 :白花蛇舌草通过促进细胞内储藏钙的释放和胞外钙离子的内流 。To study the influence of spreading hedyotis herb(SHH)on cytoplasmatic free Ca\+\{2+\} density of cervix cancer cells and its mechanism on anti cancer,the changes of free Ca\+\{2+\} were tested according to the intensity of fluorescent and based on the characteristics of fluorochrome Fura 2 which could combine with free Ca\+\{2+\} and then give off fluorescent under the condition of stimulating by some wavelength light.The results showed that SHH could stimulate the cytoplasmatic store calcium outflow and extracellular Ca\+\{2+\} inflow,and could obviously improve the density of cytoplasmatic free Ca\+\{2+\}.\;

关 键 词：白花蛇舌草 宫颈癌 宫颈癌细胞 游离钙 

分 类 号：R273[医药卫生—中西医结合]