ADSORPTION OF ^(153)Sm-EDTMP ON HYDROXYAPATITE  

作　　者：罗顺忠 谯健 蒲满飞 刘中林 赵鹏骥 傅依备 

出　　处：《Nuclear Science and Techniques》1995年第4期241-245,共5页核技术（英文）

摘　　要：Adsorption of a promising bone tumor therapeutic agent 153Sm-EDTMP (ethylene diamine tetramethylene phosphonic acid) and effects of several coexisting substances on adsorption and desorption were investigated using HA (hydroxyapatite) as an in vitro model. The adsorption is quantitative up to total deposition of 40 μmol/g HA, while nonquantitative when the complex concentration is above 40μmol/g HA in the medium of pH=7.0±0.2. The uptake increases significantly with the Ca ions added. Desorption of the adsorped complexes is in the sequence of EDTMP DTPA > EDTA. Two modes of adsorption of 153Sm-EDTMP on HA are suggested, the first one ( 40μmol/g HA) quantitatively covers the available surface and the second, by which, is less efficient, additional complexes are adsorped. Non-qualltitative adsorption is attributed to Coulomb repulsion while the complex concentration ranging from 40 to 80 μmol/g HA.

关 键 词：SM-EDTMP Bone tumor therapeutic agent HYDROXYAPATITE Adsorption and desorption Adsorption modes 

分 类 号：R815[医药卫生—放射医学] R738.1[医药卫生—临床医学]