PREPARATION OF BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS ^(153)Sm-EDTMP  

作　　者：罗顺忠 蒲满飞 谯健 刘中林 赵鹏骥 傅依备 邓侯富 

出　　处：《Nuclear Science and Techniques》1995年第3期146-149,共4页核技术（英文）

摘　　要：Samarium-153- EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for bone tumor in human beings. 153Sin with high radionuclear purity and specific activity of 5.18 GBq (140 mCi)/mg Sm2O3 was prepared by irradiating naturalSm2O3(152Sm, 26.7%) sample, replacing costly enriched samarium oxide target, at a flux of 4x 1013n.cm-2.s-1 for 110 h. The yield of 153Sm complexing with EDTMP is greater than 98% at PH 8￣10 in boiling water bath for 30 min, and not significantly decreases within one week after 153Sm-EDTMP complex formation.

关 键 词：Bone tumor Therapeutic radiopharmaceuticals 153Sm 153SM-EDTMP 

分 类 号：R817.8[医药卫生—影像医学与核医学] R738.1[医药卫生—放射医学]