萘甲异喹对大鼠心肌缺血再灌注损伤的保护作用  

PROTECTIVE EFFECTS OF NAPHTHYLMETHYL ISOQUINOLINE ON MYOCARDIAL INJURY INDUCED BY ISCHEMIA AND REPERFUSION IN RAT

作　　者：张伟[1] 桑丽萍[2] 陈义汉 

机构地区：[1]南通医学院药理学教研室,南通226001 [2]南通医学院附属医院分院药剂科 [3]上海东方医院心血管内科

出　　处：《南通医学院学报》2002年第4期393-394,399,共3页ACTA Academiae Medicinae Nantong

摘　　要：目的 :观察萘甲异喹 (NI)对氧自由基损伤心肌的影响。方法 :采用大鼠离体互作心脏 ,观察 NI对心肌缺血再灌注损伤的保护作用。结果 :NI显著保护心肌超氧化物歧化酶 (SOD)活力的降低 ;减少心肌丙二醛 (MDA)生成 ;减少心肌肌酸磷酸激酶 (CPK)释放 ;降低心肌细胞内钙聚集 ;降低再灌注诱发的室颤 (VF)和室速 (VT)发生率 ;并减轻心肌超微结构的损伤。结论 :NT对缺血再灌注损伤心肌的保护与其抗氧自由基作用有关。Objective:To study the effect of Naphtylmethyl isoquinoline(NI) on myocardial injury induced by oxygen free radical.Methods:Effects of NI on myocardial injury induced by ischemia and reperfusion were studied with isolated rat hearts.Results:NI significantly prevented reduction of superoxide dismutase(SOD) activity,decreased creatine kinase(CPK) release,reduced malondialdehyde(MDA) production,attenuated myocardial Ca 2+ accumulation,lowered incidences of ventricular fibrillation(VF) and ventricular tachycardia(VT) induced by reperfusion,and eased myocardial ultrustructural damage in comparison with the control.Conclusion:NI prevent myocardial ischemia and the action is considered to be related to the inhibition of oxygen free radical.

关 键 词：保护作用 萘甲异喹 钙拮抗剂 心肌再灌注损伤 氧自由基 丙二醛 超氧化物歧化酶 

分 类 号：R542.2[医药卫生—心血管疾病]