γ-氨基丁酸对精子顶体酶活性的影响  

Effect of γ-Aminobutyric Acid on the Sperm Acrosin Activity

作　　者：边淑玲[1] 张玮[1] 朱辉[1] 倪江[1] 姚兰春[1] 陈亮[2] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第二医院不育症门诊,黑龙江哈尔滨150086

出　　处：《中华男科学杂志》2002年第5期326-328,共3页National Journal of Andrology

基　　金：黑龙江省攻关课题 (GC0 1C14 2 0 1)

摘　　要：目的 :研究γ 氨基丁酸 (GABA)对生育男性精子及抗精子抗体 (AsAb)阳性病人的精子顶体酶活性的影响。　方法 :用BAEE ADH联合法同时测定GABA对精子顶体酶活性的影响。　结果 :GABA可明显提高正常及AsAb阳性精子顶体酶的活性 (P <0 .0 1) ;并使精子的Na+ K+ ATPase、Ca2 + ATPase、超氧化物歧化酶 (SOD)的活性增加(P <0 .0 1,P <0 .0 5 ,P <0 .0 0 1)。　结论Objectives: To investigate the effect of γ aminobutyric acid (GABA) on the sperm acrosin activity in normal men and positive antisperm antibody(AsAb) men. Methods: Sperm acrosin activity was detected by BAEE/ADH method. Results: GABA could increase the sperm acrosin activity in normal and AsAb positive patients ( P < 0.01 ). The results also indicated that GABA significantly increased Na + K + ATPase activity ( P < 0.01 ), Ca 2+ ATPase activity ( P < 0.05 ) and SOD activity( P < 0.01 ) of sperm. Conclusions: The results demonstrated that GABA could influence the sperm acrosin activity.

关 键 词：Γ-氨基丁酸 精子 顶体酶 抗精子抗体 受精能力 

分 类 号：R339[医药卫生—人体生理学]