输精管吻合术对兔睾丸细胞核雄激素受体的影响  

EFFECT OF VASOVASOTOMY ON NUCLEAR ANDROGEN RECEPTOR IN RABBIT TESTIS

作　　者：王忠山[1] 赵雪俭[1] 林桦[1] 赵丹[1] 李杨[1] 王青云[2] 刘铮[2] 张富喜[2] 

机构地区：[1]白求恩医科大学基础医学院病理生理教研室 [2]白求恩医科大学第一临床学院显微外科研究室

出　　处：《白求恩医科大学学报》1992年第4期314-316,共3页Journal of Norman Bethune University of Medical Science

基　　金：国家自然科学基金

摘　　要：31只雄性大耳白兔,分为对照组(C),输精管结扎组(V),结扎12个月后吻合生育组(VaF)和不育组(VaI)。结果是:C、V、VaF和VaI组的Kd值分别是3.11±0.55,3.87±0.70,3.54±1.13和1.69±0.32nmol/L,组间比较差异不显著(P>0.05);Bmax分别是90.59±7.46,130.48±19.16,83.24±4.34和49.98±4.37fmol/mg DNA,VaI组显著低于其余三组(P<0.01);经单点分析获各组的睾酮受体浓度分别是64.08±6.31,68.87±9.30,66.22±8.22和44.45±10.15fmol/mg DNA,VaI组显著低于其它三组(P<0.05)。Thirty-one rabbits were used in this experiment, 8 of them were grouped as the controls (C), and 23 were bilaterally vasoligated. Nine of the vasoligated ones were taken as the vasoli-gation control group (V), 14 vasooliagted animals were subdivided into the vasovasotomy fertility group (VaF) (7 rabbits) and infertility group (Val) (7 rabbits) according to their fertility 12 months after vasoligation. The nuclear androgen receptor in the testes were studied. The results were the Kd values in C. V, VaF and Val were 3. 11±0. 55. 3. 87±0. 70. 3. 54±1. 13 and 1. 69±0. 32 nmol/L with no significant difference among four groups; the Bmax was 90. 59 ±7. 46. 130. 48 ± 19. 16, 83. 24±4. 34 and 49. 98±4. 37 fmol/mg DNA with the values in Val significantly lower than those in C, V, VaF. The nuclear androgen receptor concentrations by single point analysis were 64. 08 ± 6. 31. 68. 87±9. 30, 66. 22±8. 22 and 44. 45±10. 15 fmol/mg DNA respectively , with the value in Val significantly lower than those in C, V, VaF.

关 键 词：输精管吻合 雄激素受体 细胞核 兔 

分 类 号：R699.8[医药卫生—泌尿科学]