电压门控钠通道与相关调制剂相互作用的分子机制  

Molecular mechanism of interactions between voltage-gated sodium channel and its modulators

作　　者：左小潘[1] 吉永华[1] 

机构地区：[1]中国科学院上海生命科学研究院神经生物学重点实验室,上海200031

出　　处：《中国神经科学杂志》2002年第4期736-739,748,共5页

基　　金：国家"973"项目 (19990 5 40 0 1)

摘　　要：电压门控钠通道 (VGSC)在神经元及大多可兴奋性细胞动作电位的形成和传播过程中扮演着极为重要的角色。它也是许多特异性天然动植物神经毒素作用的靶器。这些毒素可调节靶通道的各种功能活性 ,包括通道的电导、激活和失活化相等 ,进而影响电信号产生与传导过程 ,使动物麻痹 ,甚至死亡。本文从分子水平简介相关神经毒素与VGSC靶受体之间相互识别与作用的分子机制。Voltage gated sodium channels (VGSC) are responsible for the rising phase of the action potential in the membrane of neurons and most electrically excitable cells. It is targeted by a series of neurotoxins derived from plant and animal tissues as well as many synthetic pesticides. These toxicants interfere with all three fundamental functions of the VGSC, namely, the selective ion transport, activation and inactivation. Recent studies trying to determine the sites and mechanisms of these toxicants are reviewed in this paper. \[

关 键 词：电压门控钠通道 分子机制 钠离子通道 神经毒素 靶受体结合位点 VGSC 

分 类 号：R33[医药卫生—人体生理学]