东亚钳蝎毒的中枢镇痛作用  

THE ANALGESIC EFFECT OF BUTHUS MARTANSII KARSCH VENOM ON CNS

作　　者：何艳[1] 宋洪臣[1] 刘敏芝[1] 林岩松[1] 齐虹[1] 魏俊杰[2] 曹文华[2] 

机构地区：[1]白求恩医科大学生理教研室 [2]白求恩医科大学有机化学教研室

出　　处：《白求恩医科大学学报》1992年第5期421-422,共2页Journal of Norman Bethune University of Medical Science

摘　　要：向大白鼠侧脑室注入0.01％、0.03％东亚钳蝎毒液,用辐射热甩尾法测定其皮肤痛阈的变化。以pH6.4、0.01mol/L磷酸缓冲液为空白对照。实验结果表明东亚钳蝎毒有明显中枢镇痛作用。This study was designed to investigate the analgesic effect of venom of buthus martansii karsch on the central nervous system. After injection of 2μl of 0. 01% or 0. 03% scorpion venom solution into the lateral ventricle of rat. the change of pain threshold of skin was observed, it was indicated by the latent period of waving tail reflex evoked by radiant heat. Injecting 2 μl of 0. 01mol/L phosphorate buffer solution with pH 6. 4 into lateral ventricle was taken as blank control. The result suggested that the venom of buthus martansii karsch had an evidant analgesic effect on CNS.

关 键 词：东亚钳蝎毒 痛阈 止痛 蝎毒 毒素 

分 类 号：R971.1[医药卫生—药品]