实验性肌肉拉伤的生物学和生物力学研究  

Biological and biomechanical study of experimental muscle strain injury in rabbits

作　　者：舒彬[1] 吴宗耀[2] 郝林林[1] 蒋晓江[1] 聂志容[1] 肖凯[1] 林永辉[1] 

机构地区：[1]解放军第三军医大学大坪医院,重庆400042 [2]解放军第三军医大学西南医院,重庆400038

出　　处：《中国临床康复》2002年第22期3346-3347,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的探讨骨骼肌牵拉伤的生物学与生物力学特性。方法采用生物力学方法,建立肌肉拉伤的实验模型,70只兔的左胫前肌为实验肌,右胫前肌作为对照,分别在拉伤后0,1,2,3d和7d,进行组织学、酶组织化学与生物力学研究,生物力学指标包括最大肌力、断裂载荷、断裂时伸长、能量吸收与肌肉硬度。结果以相当于128%动物体重的载荷牵拉兔胫前肌,可建立肌肉拉伤的实验模型;部分肌纤维断裂和肌肉完全断裂均发生于靠近肌肉—肌腱连接处;最大肌力在拉伤后0d下降,1d时最低,7d时恢复正常;极限断裂载荷在拉伤后0d下降,2d时最低,7d时仍没有恢复正常。结论肌肉的被动强度比肌力恢复缓慢,提示拉伤肌肉易于再伤;损伤部位肌内膜纤维化和瘢痕组织形成,是肌肉拉伤后频繁复发的重要原因。Objective To explore the biological and biomec hanical property of muscle strain in jury.Methods In 70adult rabbits,the left tibialis anterior(TA)muscle received a controlled strain injury while the right TA muscle serv ed as controls.The TA muscles were studied histologically,enzyme histochemi cally and biomechanically at 0,1,2,3,and 7days post-injury.The biomechanical parameters examined were maximal contractile force,failure load,length,energy absorption and tangent stiffness to failure.Results Stretching the TA muscle under the load which equals to 128%body weight can produce an experimental muscle s train model.Partal and complete rup ture of TA muscle occurred near the muscle-tendon junction.Ma ximal contractile force decreased a t 0day,reduced the least at 1day,and almost returned to the control level at 7days post-injury.Ultimate failure load reduced at 0day,decre ased the least at 2days,and not retur nted to the control level at 7days post-injury.Conclusion Passive strength recovery is slower than maximal contractile force recovery,indicating that injured muscle may be more likely to sustain a second strain injury.The cause that muscle strain injury reoccurred may duo to endomy sium fibrosis and scar tissue formation in injured area.

关 键 词：实验性肌肉拉伤 生物学 生物力学 

分 类 号：R685[医药卫生—骨科学]