苯酚磷酰化产物的制备  

Study on the phosphorylations reaction between phenol and dialkyl phosphite

作　　者：郭蕾[1] 廖新成[2] 陈晓岚[1] 卢建莎[1] 屈凌波[2] 赵玉芬[3] 

机构地区：[1]郑州大学基础医学院有机化学教研室,郑州450052 [2]郑州大学化学系,郑州450052 [3]清华大学化学系,北京100084

出　　处：《郑州大学学报（医学版）》2002年第6期808-810,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省自然科学基金资助项目 1110 3 2 0 0 0

摘　　要：目的 :二异丙基亚磷酸酯 (DIPPH)和二乙基亚磷酸酯 (DEPH)作为磷酰化试剂 ,对苯酚进行磷酰化。方法 :冰盐浴条件 ,DIPPH(DEPH)和四氯化碳的混合液逐滴加到苯酚 ,三乙胺 ,二氧六环的混合液中。滴加完毕 ,室温搅拌数小时 ,苯酚和DIPPH(DEPH)生成磷酸酯。结果与结论 :核磁共振测定仪和电喷雾电离质谱 (ESI MS)检测到产物的存在 。Aim: To study the reaction of phenol and dialkyl phosphite. Methods: Phenol was phosphorylated by DIPPH and DEPH respectively by Atherton Todd reaction,by dropping the DIPPH and DEPH and tetrachloromethane into the mixed solution of phenol,triethylamine and dioxane. Results and discussion: The aim products including diethyl phenyl phosphate and diisopropyl phenyl phosphate were successfully synthesized under the condition mentioned .The target products were further determined by 31PNMR, 1HNMR and ESI MS.

关 键 词：苯酚 磷酰化产物 制备 

分 类 号：O625.31[理学—有机化学]