改进相转移催化法合成2-甲基苯基-4′-硝基苯基醚化合物  

An Improved Method of Phase Transfer Catalyst for the Synthesis of 2-Methylphenyl-4′-Nitro Phenyl Ether

作　　者：邹长军[1] 刘丽波[2] 

机构地区：[1]西南石油学院化学化工学院,四川成都市610500 [2]东北电力学院轻工系,吉林吉林市132002

出　　处：《石油化工高等学校学报》2002年第4期51-53,共3页Journal of Petrochemical Universities

摘　　要：以聚乙二醇 (PEG6 0 0 )为相转移催化剂 ,对硝基氯苯和邻甲基苯酚为原料 ,在K2 CO3 存在下 ,甲苯作溶剂固 -液相反应合成了 2 -甲基苯基 - 4′-硝基苯基醚化合物。采用统计序贯实验设计方法寻优 ,综合考察了影响反应的诸因素 ,得到了最佳反应条件 ,n(对硝基氯苯 )∶n(邻甲基苯酚 )∶n(催化剂 ) =1∶1.0 8∶0 .0 8,反应时间为 5h。讨论了相转移催化机理。实验结果表明 ,聚乙二醇 (PEG6 0 0 )为相转移催化剂在本反应中表现出较强的络合K+的能力 ,催化效果明显优于其它分子质量的聚乙二醇为相转移催化剂 ,该工艺反应平稳 ,2 -甲基苯基 - 4′ -硝基苯基醚的收率达到 92 %。The technology for synthesis of 2-methylphenyl-4′-nitro phenyl ether was studied by means of solid-liquid phase transfer catalysis. Polyethylene glycol 600 was selected as catalyst and sequential discriminant procedure method used in its synthesis. The result indicates that the sequential discriminant procedure method for design of experiments is very useful. Polyethylene glycol 600 has high capacity to complex K +, Under the optimum conditions, p -nitrochlorobenzene∶ o -cresol∶ PEG600=1.00 ∶1.08∶0.08 (mole ratio), reaction time 5 h, the yield of 2-methylphenyl-4′-nitro phenyl ether is 92%, the present procedure has advantages of high yield and simplicity in operation.

关 键 词：改进 相转移催化法 合成 2-甲基苯基-4'-硝基苯基醚 固-液相转移催化 统计序贯实验设计方法 

分 类 号：TQ243.24[化学工程—有机化工]