小剂量HpD配合可变脉宽532nm激光治疗鲜红斑痣的实验研究  被引量:1

Experimental Study on Port-Wine Stain Treated by Small Dose HpD and Variable Pulsed 532nm Laser

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作  者:秦梅香[1] 朱菁[1] 袁霞雯[1] 张慧国[1] 包晓青[1] 周琳[1] 施虹敏[1] 张美珏[1] 聂凡[1] 

机构地区:[1]上海第二医科大学附属仁济医院

出  处:《应用激光》2002年第5期502-506,共5页Applied Laser

基  金:上海市科技发展基金(编号994119061)

摘  要:目的:为寻求治疗鲜红斑痣疗效佳、对正常皮肤损伤小、副反应小的方法。方法:以不同剂量HpD配合不同剂量带同步冷却装置的532nm激光分成四个治疗组,照射鲜红斑痣动物模型来克享大公鸡鸡冠,并与单纯激光组比较,激光治疗前及治疗后6周进行疗效评估。结果:5个组间疗效有非常显著的差异(p<0.01),治疗组的疗效优于对照组。四个治疗组间疗效有差异(p<0.05),提高HpD剂量可提高疗效。任一组能量密度组间疗效有差异(p<0.05),提高能量密度可提高疗效。结论:小剂量HpD配合可变脉宽532nm激光治疗鲜红斑痣可以提高疗效。提高能量密度和HpD剂量可提高疗效。Objective:To obtain a new therapy of port-wine stain (PWS) with good effect and few side effects. Methods: the Leghorn combs chosen as the model and treated with small dose HpD and variable pulsed 532nm laser were evaluated clinically using four different scoring systems commonly used in previous publication. Results: It was shown significant difference among 5 groups (p<0. 01) , and the treatment groups have better effect than the control group. There's also difference among the four treatment groups and the higher dose of HpD has better effect. In all groups the higher the fluency of laser was usedm, the better the effect produced. Conclusion: The results provide evidence that small dose HpD and variable pulsed 532nm laser can increase the efficacy of treatment in PWS. Increasing the fluency of laser and the dose of HpD can improve the efficacy.

关 键 词:鲜红斑痣 HPD 激光治疗 可变脉宽激光 

分 类 号:R758.61[医药卫生—皮肤病学与性病学] R454.2[医药卫生—临床医学]

 

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