Electron microscopic observations and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by ^(153)Sm-EDTMP  

作　　者：Zhu Shou Peng, Xiao Dong and Han Xiao Feng ( Suzhou Medical College, Suzhou 215007) 

出　　处：《Nuclear Science and Techniques》1997年第3期163-165,共3页核技术（英文）

摘　　要：ＥｌｅｃｔｒｏｎｍｉｃｒｏｓｃｏｐｉｃｏｂｓｅｒｖａｔｉｏｎｓａｎｄＤＮＡｃｈａｉｎｆｒａｇｍｅｎｔａｔｉｏｎｓｔｕｄｉｅｓｏｎａｐｏｐｔｏｓｉｓｉｎｂｏｎｅｔｕｍｏｒｃｅｌｓｉｎｄｕｃｅｄｂｙ１５３ＳｍＥＤＴＭＰＺｈｕＳｈｏｕＰｅｎｇ，Ｘｉａ...The morphological changes observed by electron microscopy indicate that after internal irradiation with 153 Sm EDTMP bone tumor cells displayed feature of apoptosis, such as margination of condensed chromatin, chromatin fragmentation,as well as the membrane bounded apoptotic bodies formation. The quantification analysis of fragmentation DNA for bone tumor cells induced by 153 Sm EDTMP shows that the DNA fragmentation is enhanced with the prolongation of internally irradiated time. These characteristics suggest that 153 Sm EDTMP internal irradiation could induce bone tumor cells to go to apoptosis.

关 键 词：DNA 胃癌细胞 153SM-EDTMP 

分 类 号：R817.8[医药卫生—影像医学与核医学] R735.[医药卫生—放射医学]