Labeling　and　stability　study　On^（99m）Tc－tissue　plasminogen　activator　as　thrombus　and　tumor　imaging　agent  

作　　者：李卫一 曹国宪 俞惠新 张荣军 

出　　处：《Nuclear Science and Techniques》1996年第1期45-47,共3页核技术（英文）

摘　　要：ＬａｂｅｌｉｎｇａｎｄｓｔａｂｉｌｉｔｙｓｔｕｄｙＯｎ￣（９９ｍ）Ｔｃ－ｔｉｓｓｕｅｐｌａｓｍｉｎｏｇｅｎａｃｔｉｖａｔｏｒａｓｔｈｒｏｍｂｕｓａｎｄｔｕｍｏｒｉｍａｇｉｎｇａｇｅｎｔＬｉＷｅｉ－Ｙｉ（李卫一），ＣａｏＧｕｏ－Ｘｉａｎ（曹国宪），Ｙｕ...Tissue plasminogen activator (tPA), due to its stability in acidic solution, could be conveniently labeled with 99mTc by using stannous chloride method. More than 90% of biochemical activity was remained after the process of labeling and separation. The stability of 99mTc-tPAc was studied at different time and different pH Values, respectively. The study indicates that 99mTc-tPA would be a potential imaging agent for thrombus and tumor.

关 键 词：血栓 肿瘤 造影剂 ^99MTC 

分 类 号：R814.43[医药卫生—影像医学与核医学]