再生障碍性贫血患者骨髓和外周血中FL水平的测定及意义  

DETECTION OF FLT3-LIGAND LEVEL IN THE BONE MARROW AND PERIPHERAL BLOOD OF THE PATIENTS WITH APLASTIC ANEMIA AND ITS SIGNIFICANCE

作　　者：季玉红[1] 钱绩虎[1] 傅晋翔[2] 张学光[2] 

机构地区：[1]南通医学院微生物学教研室,南通226001 [2]苏州大学生物技术研究所

出　　处：《南通医学院学报》2002年第4期376-377,共2页ACTA Academiae Medicinae Nantong

基　　金：国际原子能机构资助项目 (CRP/ 0 2 5 )

摘　　要：目的 :测定再生障碍性贫血 (AA)患者骨髓 (BM)和外周血 (PB)中酪氨酸激酶受体 3的配体 (FL)的水平 ,并探讨其意义。方法 :用常规 EL ISA法检测 16例再障患者骨髓和外周血中 FL、s Fas L和 IL - 2的水平。结果 :再障患者骨髓和外周血中 FL 水平显著升高 ,为正常对照的 2 0倍以上 (P<0 .0 1)。再障患者骨髓及外周血中 s Fas L、IL- 2含量也明显高于正常对照组 (P <0 .0 1)。结论 :再障患者骨髓和外周血中 FL、s Fas L、IL - 2含量与患者疾病的严重程度呈负相关。Objective:To investigate Flt3-ligand level in the bone marrow(BM) and peripheral blood(PB) of the patients with aplastic anemia (AA) and its significance.Methods: The levels of FL in the BM and PB from 16 Patients with AA were detected by ELISA.Results:The levels of FL, sFasL, IL-2 increased in patients BM and PB with AA. The level of FL was more significant (P<0.01).Conclusion:The level of FL in patients BM and PB with AA was negatively correlated with the course of AA.

关 键 词：骨髓 外周血 再生障碍性贫血 酪氨酸激酶受体3 配体 测定 

分 类 号：R556.5[医药卫生—血液循环系统疾病]