Synthesis and radioiodinated labeling of p-iodophenylpentadecanoic acid  

作　　者：WuChun－Ying JiShu－Ren 等 

机构地区：[1]JiangsuInstituteofNuclearMedicine,StateKeyLaboratoryofNuclearMdicine,Wuxi214063 [2]JiangsuInstituteofNuc

出　　处：《Nuclear Science and Techniques》1998年第4期246-250,共5页核技术（英文）

摘　　要：A new method for tile preparation of p-iodophenyl pentadecanoic acid (IPPA)has been developed. The synthesis are described, and physical properties of IPPA are characterized by IR, 1HNMR, elementary analysis and MS. 125I-IPPA can be easily prepared bytwo methods: direct labeling and solid-phase iodo-exchange labeling, and the yields of labelingare 80% and 65%, respectively. The radiochcnrical purities are higher than 98% after beingextracted with chloroform and he-cane.A new method for tile preparation of p-iodophenyl pentadecanoic acid (IPPA)has been developed. The synthesis are described, and physical properties of IPPA are characterized by IR, 1HNMR, elementary analysis and MS. 125I-IPPA can be easily prepared bytwo methods: direct labeling and solid-phase iodo-exchange labeling, and the yields of labelingare 80% and 65%, respectively. The radiochcnrical purities are higher than 98% after beingextracted with chloroform and he-cane.

关 键 词：放射性碘示踪 对十五烷酸碘苯酯 合成 

分 类 号：R817.4[医药卫生—影像医学与核医学]