Action of ZDY101 on passive avoidance test and brain M-receptor density after intracranial co-injection of Aβ plus ibotenic acid  

作　　者：HUYa－Er XIAZong－Qin 等 

机构地区：[1]ResearchLaboratoryofCellRegulation,ShanghaiSecondMedicalUniversity,Shanghai200025

出　　处：《Nuclear Science and Techniques》2001年第4期250-255,共6页核技术（英文）

基　　金：Supported by the National Natural Science Foundation of China (39570835)

摘　　要：The aim of this study was to establish a model by single injection of Aβ1-40+IA into rat brain basal ganglion and examine the effect of ZDY101, an active component of a Yin tonic from Chinese traditional medicinal herb. The results showed that the amnestic effect of co-injection of Aβ and IA lasted for at least 2 months. At same time, the total M-receptor density in model brain was significantly lower than blank control, indicating the change is profound enough for long term pathological studies or drug screening. It can be clearly seen that the decreased brain M-receptor density caused by Aβ was significantly increased by ZDY101. Such an elevation effect was significantly correlated with dose of ZDY101 when the dose was examined in a certain reasonable range. It can also he clearly seen that such an elevation of M-cholinergic receptor density was significantly correlated with the improvement of memory which indicated that the increase of M-cholinergic receptor density was an important factor in improving the memory of such animal model.The aim of this study was to establish a model by single injection of Aβ1-40+IA into rat brain basal ganglion and examine the effect of ZDY101, an active component of a Yin tonic from Chinese traditional medicinal herb. The results showed that the amnestic effect of co-injection of Aβ and IA lasted for at least 2 months. At same time, the total M-receptor density in model brain was significantly lower than blank control, indicating the change is profound enough for long term pathological studies or drug screening. It can be clearly seen that the decreased brain M-receptor density caused by Aβ was significantly increased by ZDY101. Such an elevation effect was significantly correlated with dose of ZDY101 when the dose was examined in a certain reasonable range. It can also he clearly seen that such an elevation of M-cholinergic receptor density was significantly correlated with the improvement of memory which indicated that the increase of M-cholinergic receptor density was an important factor in improving the memory of such animal model.

关 键 词：放射医学 Alzeimer病 动物模型 

分 类 号：R817[医药卫生—影像医学与核医学] R749.16[医药卫生—放射医学]