SCD_(14)、TNF-α、E-SLT及IL-10在感染发病中的作用及临床意义  

Changes of SCD_(14)、TNF-α、E-SLT and IL-10 level in the process of infection

作　　者：杨镛[1] 罗开元[2] 时德[3] 段志泉[1] 

机构地区：[1]中国医科大学附属第一医院血管外科,沈阳110001 [2]云南省第二人民医院普外科 [3]重庆医科大学附属第一医院血管外科

出　　处：《中华普通外科杂志》2002年第11期688-689,共2页Chinese Journal of General Surgery

摘　　要：目的探讨SCD14 、TNF α、E SLT及IL 10在感染发病机制中的作用及其意义。方法采用酶联免疫吸附法测定 37例腹部外伤合并感染患者及内毒素血症兔模型中可溶性CD14 (SCD14 )、肿瘤坏死因子α(TNF α)、E选择素 (E SLT)及白细胞介素 10 (IL 10 )血清浓度变化情况。结果与对照组相比 ,SCD14 与TNF α在术后第 1天开始升高 ,E SLT与IL 10在术后合并感染组中于第 3天出现增高〔(1 6 1± 0 47) μg/ml与 (2 8 6 3± 8 2 9)pg/ml,(15 3 6± 48 9)ng/ml与 (38 2 1± 10 87)pg/ml,P均 <0 0 5〕 ;在兔内毒素血症中则分别于第 30、12 0min开始增高〔(0 5 0± 0 0 2 ) μg/ml与 (1 0 0± 0 0 2 )pg/ml,(2 0 9± 0 5 )ng/ml与 (4 9 7± 0 5 )pg/ml,P均 <0 0 5〕。结论　血清SCD14 、TNF α、E SLT及ILObjective To investigate the changes of SCD 14, TNF-α, E-SLT and IL-10 level in the process of infection.Methods Serum E-SLT, IL-10, SCD 14 and TNF-α level was measured in 37 patients of abdominal trauma, and in model rabbits with endotoxemia.Results Serum level of SCD 14,TNF-α,E-SLT and IL-10 on the 1st to 3rd day post-op increased significantly in patients suffering from post-op infection 〔(1.61±0.47)?μg/ml, (28.63±8.29)?pg/ml,(153.6±48.9)?ng/ml and (38.21±10.87)?pg/ml, compared with control, all P<0.05〕.The respective parameters in rabbits with endotoxemia increased significantly 〔(0.50±0.02)?μg/ml, (1.00±0.02)?pg/ml,(20.9±0.5)?ng/ml and (49.7±0.5)?pg/ml, compared with control, all P<0.05〕. Conclusions The level of SCD 14, TNF-α,IL-10 and E-SLT was in response to the development of infection and the prognosis of the patients with infection.

关 键 词：SCD14 TNF-Α E-SLT IL-10 腹部外伤 感染 内毒素血症 酶联免疫吸附法 动物模型 

分 类 号：R630.2[医药卫生—外科学]