干扰素-α联合复方丹参对慢性乙型肝炎血清肝纤维化指标和细胞因子的影响  

CHANGE OF SERUM FIBROSIS MARKERS AND CYTOKINES IN CHRONIC HEPATITIS B AFTER COMBINATION THERAPY WITH INTERFERON-α AND COMPOUND SALVIA MILTIORRHIZA

作　　者：孔丽[1] 李兵顺[1] 米立军[1] 任仲轩[1] 刘金星[1] 刘芳[1] 

机构地区：[1]河北医科大学第三医院感染科,河北石家庄050051

出　　处：《河北医科大学学报》2002年第6期321-323,共3页Journal of Hebei Medical University

基　　金：河北省科技攻关计划项目 ;项目号 (992 761178)

摘　　要：目的观察干扰素 α(interferon α ,IFN α)与复方丹参合用对慢性乙型肝炎血清肝纤维化指标和细胞因子的影响。方法 70例患者随机分为IFN组和IFN α与复方丹参联合组 (联合组 ) ,观察治疗前后血清HA、PCⅢ、Ⅳ C、IL 6、IL 8的动态变化。结果治疗前慢性乙型肝炎患者血清HA、PCⅢ、Ⅳ C、IL 6、IL 8均明显高于正常(P <0 .0 1) ;治疗后各指标显著降低 (P <0 .0 5或P <0 .0 1) ,联合组HA、PCⅢ、IL 6较IFN组降低明显 (P <0 .0 5 )。IFN和联合治疗前治疗无效组HA、PCⅢ显著高于有效组 (P <0 .0 5或P <0 .0 1) ,治疗后HA、PCⅢ有效组和无效组均显著降低 (P <0 .0 5或P <0 .0 1) ;Ⅳ C、IL 6、IL 8治疗前无差异 ,治疗后降低 ,有效组较无效组降低明显 (P <0 .0 5或P <0 .0 1)。结论IFN α和复方丹参合用有助于减轻慢性乙型肝炎炎症坏死和纤维化程度 ;ObjectiveTo observe the changes of serum fibrosis markers and cytokines levels in chronic hepatitis B after combination therapy with IFN α and compound salvia miltiorrhiza (cpdSM). MethodsSeventy patients with chronic hepatitis B were divided into IFN group and combination group. The patients in IFN group received IFN α therapy and those in combination group received IFN α and cpdSM combination therapy. The serum levels of fibrosis markers including HA, PCⅢ, IV C and cytokines including IL 6, IL 8 were determined. ResultsBefore treatment, the levels of serum HA, PCⅢ, IV C,IL 6,IL 8 in patients with chronic hepatitis B were higher than those in normal control(P< 0.01 ). After treatment, the levels reduced significantly( P< 0.05 or P< 0.01 ). Serum HA, PCⅢ, IL 6 levels in combination group were lower than IFN group( P< 0.05 or P< 0.01 ). Before treatment with IFN α or combination therapy, serum HA, PCⅢ levels in non responders were higher than those in responders(P< 0.05 or P< 0.01 ). After treatment the levels of HA, PCⅢ decreased in both responders and non responders( P< 0.05 or P< 0.01 ). No differences in the levels of IV C,IL 6,IL 8 between responders and non responders could be found before treatment, but after treatment the levels of IV C,IL 6,IL 8 in responders were lower than those in non responders(P< 0.05 or P< 0.01 ). ConclusionThese results suggest that combination therapy with IFN α and cpdSM may decrease the pathological changes of inflammation, necrosis and fibrosis of hepatic tissue in patients with chronic hepatitis B. High serum HA, PCⅢ levels before treatment may be related to a poor response to IFN or combination therapy with IFN and cpdSM.

关 键 词：乙型肝炎 肝硬化 干扰素-Α 丹参 治疗 

分 类 号：R512.620.5[医药卫生—内科学]