碱性成纤维细胞生长因子鼓室给药治疗感音神经性聋的研究  

The therapeutic effects of basic fibroblast growth factor injected into tympanic cavity on sensorineural deafness

作　　者：张志坚[1] 刘宜娟 窦毅[2] 孙高灿[2] 黄秋生[2] 郭小平[2] 

机构地区：[1]江苏大学医学院基础与临床医学研究中心,江苏镇江212001 [2]江苏大学附属医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》2002年第11期603-605,共3页Journal of Clinical Otorhinolaryngology

基　　金：基金项目:江苏省卫生厅指导性项目(No.Z9508);省教委科研试验发展基金资助项目(苏教计[1995]25号)

摘　　要：目的:探讨碱性成纤维细胞生长因子治疗感音神经性聋的临床应用价值及鼓室局部给药的可行性。方法:随机选择本院1998～1999年收治的感音神经性聋患者40例(50耳),碱性成纤维细胞生长因子(bFGF)作鼓膜穿刺鼓室内给药。治疗前后进行纯音测听,定期随访,追踪观察bFGF的疗效。结果:经bFGF治疗后,患者语频、高频及0.25～4 kHz各频率的听阈平均值均有明显提高,分别与治疗前比较,差异有极显著性意义(P<0.01)。总有效率为96％,其中治愈率8％,显效率38％,好转率50％。除有轻度胀痛外,无其他不良反应。结论:鼓室局部应用bFGF治疗感音神经性聋疗效明显,方法可行。Objective:To evaluate the therapeutic effects of basic fibroblast factor (bFGF) ototopically injected into tympanic cavity on sensorineural deafness. Method; 40 cases(50 ears) suffering from sensorineural deafness have been treated with bFGF, which was injected into tympanic cavity from 1998 to 1999. The hearing threshold of post-therapy was compaired with that of pre-therapy. Result; The total therapeutic effective rate of bFGF on the deafness was 96%. The hearing threshold of pos'-therapy was much lower than that of pre-therapy in average. Conclusion; The bFGF could improve the hearing of sensorineural deafness patients. The method of ototopically injecting bFGF to tympanic cavity was safe and applicable.

关 键 词：鼓室给药 感音神经性聋 碱性成纤维细胞生长因子 疗效 

分 类 号：R764.431[医药卫生—耳鼻咽喉科]