湿热证动物模型微量元素、维生素E变化及清香散的调节作用  

Changes of Trace Elements,Vitamin E in Animal Test Models with Wetness-heat and Regulating Function of Qingxiangsan

作　　者：刘立[1] 杨运高[1] 吴仕九[1] 李亦晗 

机构地区：[1]第一军医大学中医系,广州510515

出　　处：《广东微量元素科学》2002年第7期33-36,共4页Trace Elements Science

基　　金：广东省科委自然科学基金资助课题 (No 95 0 5 6 )

摘　　要：采用多因素造模方法复制成湿热证动物模型 ,观察了动物模型微量元素Zn、Cu、Fe、Se和维生素E代谢水平的变化。结果显示 ,模型动物血清Zn下降 (P <0 0 5 ) ,Cu升高 (P <0 0 5或P <0 0 1 ) ,Fe变化不大 (P >0 0 5 ) ,血Se水平下降 (P <0 0 5 ) ,血浆维生素E含量减少 (P<0 0 1 )。经清热祛湿的经验方清香散治疗后 ,治疗Ⅰ组动物血清Zn、血Se、血浆维生素E明显升高 (P <0 0 5 ) ,血清Cu下降 (P <0 0 5 ) ;治疗Ⅱ组血浆血清Cu有变化 (P <0 0 5 )外 。Animal test models with wetness heat syndrome are made by multi factors ways so as to observe the metabolic changes of some trace elements,like Zn,Cu,Fe,Se and vitamin E.The result indicates that Zn in blood serum of animal test model goes down( P <0 05)and Cu goes up( P< 0 05 or P <0 01),while serum Fe( P >0 05)has no significant change;Se( P <0 05)in blood declines and so does vitamin E in blood plasma declines.After the animal test models are treated by Qingxiangsan,an effective recipe to clear away heat evil and wetness evil,Zn in blood serum,Se in blood and vitamin E in blood plasma of group Ⅰ increases distinctly( P <0 05)and Cu in blood serum goes down( P <0 05);data of group Ⅱ has changed little except Cu in blood serum( P <0 05).

关 键 词：湿热证 微量元素 维生素E 清香散 病理学 药理学 

分 类 号：R25[医药卫生—中医内科学] R285[医药卫生—中医学]