孕早期妇女碘营养及垂体-甲状腺功能  

Iodine Nutrition and Pituitary-Thyroid Function of Early Pregnant Women

作　　者：黄薇[1] 李思果[2] 王继尧[1] 魏若飞[1] 罗若荣[1] 王晓华[1] 

机构地区：[1]深圳市疾病预防控制中心,518020 [2]华中科技大学同济医学院

出　　处：《中国公共卫生》2002年第11期1288-1289,共2页Chinese Journal of Public Health

基　　金：深圳市科技计划经济资助课题 (2 0 0 2 0 4 1 2 7)

摘　　要：目的　揭示妊娠早期对妇女碘营养和垂体 -甲状腺功能的影响。方法　一次性收集连续居住在深圳市 3年以上 ,经济收入中等 ,受孕第 12～ 14周妇女尿及全血 ,采用砷铈催化分光光度法测定尿碘和血清碘 ,化学发光法测定垂体 -甲状腺激素。结果　 110例早孕组尿碘 14 6 5 μg/L及血清碘 (82 2 μg/L)明显低于 110例未孕组 (2 93μg/L和90 8μg/L ,P均 <0 0 1) ;其中 70例早孕组FT4(15 2 5 pmol/L)低于未孕组 (16 75 pmol/L ,P <0 0 1) ;FrT3 /FT4(0 331)和TSHs(2 4 1mU/L)明显高于未孕组 (0 314和 1 84mU/ ,P均 <0 0 1)。而早孕组尿碘 <10 0 μg/L有 14 5 %高于未孕组 5 2 % (P <0 0 5 )。结论　在碘营养充足地区早孕第 12～ 14周妇女碘营养和垂体 -甲状腺功能可发生变化。体内碘储备已开始下降 ,FT4降低 ,而TSHs开始增高 ,其中有 3例 (4 3% )超过临床参考值 。Objective In order to reveal the effects of iodine nutrition and pituitary-thyroid function during early pregnancy.Methods To collect urine and vein blood in pregnant women(12-14 weeks) who lived in the city for more than 3 years and earned medium income.To use As()-Ce 4+ catalytic spectrophotometry to measure urine iodine content and use Automated Chemiluminescence System to test pituitary-thyroid hormones.Results Urine iodine(146.5μg/L) and serum iodine(82.2μg/L) of 110 early pregnant women group showed significantly lower compared with that of 115 nonpregnant group(293μg/L and 90.8μg/L, P av <0 01).Free thyroxine (FT 4) level(15 25pmol/L) of 70 early pregnant women group were lower than the nonpregnant group (16.75pmol/L and P <0 01).FrT 3/FT 4(0.331) and thyroid stimulating hormone(TSHs,2.41mU/L) was higher than the nonpregnant group(0.314 and 1 84mU/L, P av <0 01).Urine iodine of early pregnant women less than 100μg/L were 14.5%,and was higher than 5 2% of nonpregnant women( P <0 05).Conclusion Iodine nutrition and pituitary-thyroid function during pregnancy(12-14 weeks)took place changes in iodine sufficient area.Iodine reserved in body decreased in early pregnancy,FT 4 also decreased,and yet TSHs increased on the contrary.TSHs level of 3 cases (4.3%) of early pregnancy group went beyond clinical reference intervals.Therefore,the prevention and cure of IDD should start before pregnancy.

关 键 词：碘营养 垂体-甲状腺功能 早孕 血碘 尿碘 垂体-甲状腺激素 化学发光法 碘缺管病 IOD 

分 类 号：R714.256[医药卫生—妇产科学]