嗅鞘细胞生物学特性及其在脊髓再生中应用的研究  

Biological Characterizations and Application of Olfactory Ensheathing Cells in Regeneration of Spinal Cord

作　　者：杨浩[1] 梁哲[1] 游思维[1] 鞠躬[1] 

机构地区：[1]第四军医大学全军神经科学研究所,陕西西安710032

出　　处：《动物医学进展》2002年第6期28-32,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金(3 0 0 70 799);国家"973"课题项目"脑功能和脑重大疾病的基础研究子课题:脊髓损伤修复的基础研究"课题项目(G19990 5 40 0 9)

摘　　要：近年来研究证明嗅球及嗅神经组织可以分离出嗅神经鞘细胞 (olfactory ensheathingcells,OECs) ,OECs具有中枢神经系统 (CNS)星形胶质细胞和外周雪旺式细胞的特性 ,移植后的 OCEs能够在宿主损伤的脊髓组织进行迁移 ,能够引导支持损伤的神经元突起再生、生长、延伸。而且还可以通过转基因技术使其携带某些促进神经元再生的外源性基因 ,表达一些促神经再生的分子 ,从而改善神经损伤的内环境 ,诱导损伤的脊髓神经元再生 ,使得受损脊髓再生的潜力得以发挥 ,达到脊髓再生和功能恢复的目的。本文就Recent studies have revealed that Olfactory ensheathing cells (OECs) are distributed within Olfactory ensheathing bulbs,Olfactory epithelium and Olfactory nerve. The cell can exhibit phenotypic and functional properties known to both Schwan cell in peripheral nervous system and astrocyte in central nervous system.When OECs were transplanted into injured areas of spinal cord ,these cells are able to survive and migrate in the injured location.Furthermore, The injured neuronal axonal regeneration,neurite growth and elongation are supported and guided with accompanying OECs migration. In addtion, Transgenic technological application might be undertaken to develop OECs carrying exgenous genes,which mediate neuronal regeneration in Spinal cord. With expression of these molecules,The appropriate environment for injured areas of nervous regeneration was created, and The potential of spinal cord regeneration manifested and the purpose of spinal cord funcational recovery would be achieved.In this article,The OECs biological properties,its application in spinal cord injury and genic therapy in CNS are reviewed.

关 键 词：嗅鞘细胞 生物学特性 脊髓再生 应用 细胞移植 脊髓损伤 基因治疗 

分 类 号：Q421[生物学—神经生物学] R651.2[生物学—生理学]